Seroatlas · Human Serome Atlas

SHISAL1

Protein shisa-like-1

Also known as: KIAA1644, SHSL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3SXP7
Gene
SHISAL1
Ensembl
ENSG00000138944
Chromosome
22
Canonical length
199 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q3SXP7|SHISAL1
     1  MTSCGQQSLN VLAVLFSLLF SAVLSAHFRV CEPYTDHKGR YHFGFHCPRL SDNKTFILCC
    61  HHNNTVFKYC CNETEFQAVM QANLTASSEG YMHNNYTALL GVWIYGFFVL MLLVLDLLYY
   121  SAMNYDICKV YLARWGIQGR WMKQDPRRWG NPARAPRPGQ RAPQPQPPPG PLPQAPQAVH
   181  TLRGDAHSPP LMTFQSSSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 29 nTPM
  • smooth muscle: 27 nTPM
  • cerebral cortex: 27 nTPM
  • amygdala: 24 nTPM
  • cervix: 19 nTPM
  • colon: 18 nTPM

Single-cell type

  • lactotrophs: 21 nCPM
  • smooth muscle cells: 20 nCPM
  • other brain neurons: 19 nCPM
  • decidual stromal cells: 18 nCPM
  • brain inhibitory neurons: 12 nCPM
  • brain excitatory neurons: 11 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 123 nTPM
  • cerebral cortex: 75 nTPM
  • amygdala: 71 nTPM
  • midbrain: 63 nTPM
  • basal ganglia: 61 nTPM
  • hypothalamus: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0.04
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISAL1 as an antibody target. Whether an autoantibody or antibody against SHISAL1 could matter depends on whether native SHISAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHISAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHISAL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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