Seroatlas · Human Serome Atlas

SHISAL2A

Protein shisa-like-2A

Also known as: FAM159A, MGC52498, SHL2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWV7
Gene: SHISAL2A
Ensembl: ENSG00000182183
Chromosome: 1
Canonical length: 190 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q6UWV7|SHISAL2A
     1  MSGACTSYVS AEQEVVRGFS CPRPGGEAAA VFCCGFRDHK YCCDDPHSFF PYEHSYMWWL
    61  SIGALIGLSV AAVVLLAFIV TACVLCYLFI SSKPHTKLDL GLSLQTAGPE EVSPDCQGVN
   121  TGMAAEVPKV SPLQQSYSCL NPQLESNEGQ AVNSKRLLHH CFMATVTTSD IPGSPEEASV
   181  PNPDLCGPVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISAL2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

lymph node: 5.3 nTPM
tonsil: 4.8 nTPM
spleen: 4.3 nTPM
hypothalamus: 3.9 nTPM
small intestine: 2.9 nTPM
appendix: 2.2 nTPM

Single-cell type

b-cells: 103 nCPM
t-cells: 37 nCPM
neutrophils: 34 nCPM
nk-cells: 33 nCPM
innate lymphoid cells: 32 nCPM
bergmann glia: 25 nCPM

Immune cell

memory B-cell: 10 nTPM
naive B-cell: 9.8 nTPM
gdT-cell: 7 nTPM
memory CD4 T-cell: 6.3 nTPM
NK-cell: 5.9 nTPM
memory CD8 T-cell: 5.6 nTPM

Brain region

hypothalamus: 18 nTPM
midbrain: 2.8 nTPM
thalamus: 2.8 nTPM
white matter: 2 nTPM
medulla oblongata: 1.8 nTPM
pons: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHISAL2A as an antibody target. Whether an autoantibody or antibody against SHISAL2A could matter depends on whether native SHISAL2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHISAL2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHISAL2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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