SHISA7

Protein identityUniProt · HPA

UniProt accession

A6NL88

Gene

SHISA7

Ensembl

ENSG00000187902

Chromosome

19

Canonical length

538 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Cytosol

OverviewNCBI Gene

Predicted to enable GABA receptor binding activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>A6NL88|SHISA7
     1  MPALLLLVLL ASSAGQARAR PSNATSAEPA GPLPALLAHL RRLTGALTGG GGAASPGANG
    61  TRTGPAGGAG AAARAPPPAE LCHGYYDVMG QYDATFNCST GSYRFCCGTC HYRFCCEHRH
   121  MRLAQASCSN YDTPRWATTP PPLAGGAGGA GGAGGGPGPG QAGWLEGGRT GGAGGRGGEG
   181  PGGSTAYVVC GVISFALAVG VGAKVAFSKA SRAPRAHRDI NVPRALVDIL RHQAGPGTRP
   241  DRARSSSLTP GIGGPDSMPP RTPKNLYNTV KTPNLDWRAL PPPSPSLHYS TLSCSRSFHN
   301  LSHLPPSYEA AVKSELNRYS SLKRLAEKDL DEAYLKRRPL ELPRGTLPLH ALRRPGTGGG
   361  YRMEAWGGPE ELGLAPAPNP RRVMSQEHLL GDGGRSRYEF TLPRARLVSQ EHLLLSSPEA
   421  LRQSREHLLS PPRSPALPPD PTARASLAAS HSNLLLGPGG PPTPLRGLPP PSSLHAHHHH
   481  ALHGSPQPAW MSDAGGGGGT LARRPPFQRQ GTLEQLQFIP GHHLPQHLRT ASKNEVTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHISA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

25 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0.85

gnomAD missense Z

1.74

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• gamma-aminobutyric acid receptor clustering
• gamma-aminobutyric acid signaling pathway
• memory
• positive regulation of long-term synaptic potentiation
• regulation of GABA-A receptor activity

Molecular functions

• GABA receptor binding

Cellular components

• dendritic spine membrane
• postsynaptic density
• postsynaptic density membrane
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• Shisa
• Shisa, N-terminal domain
• Shisa, N-terminal domain

KeywordsUniProt

• Cell membrane
• Glycoprotein
• Membrane
• Phosphoprotein
• Postsynaptic cell membrane
• Signal
• Synapse
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SHISA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GABA
• GABRA1
• GABRA2
• GABRG2