E-box Binding Transcriptional Regulators
IPR050283
Definition
The protein family functions as transcriptional regulators with diverse roles in development, differentiation, and metabolism. Members of the family are characterized by their ability to bind E-box consensus sequences (5'-CANNTG-3') and modulate gene expression. They are involved in processes such as myogenesis inhibition, neurogenesis, cardiac morphogenesis, pancreas development, limb development, and epithelial-mesenchymal interactions. Some act as transcriptional repressors, while others form heterodimers with E proteins to activate or repress transcription. They play roles in cell fate determination, maintenance of stem cell pluripotency, and regulation of metabolic pathways. The family includes factors that are essential for the development of specific tissues and organs, and for the maintenance of homeostasis in adult tissues.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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