SCX
Basic helix-loop-helix transcription factor scleraxis
Also known as: bHLHa41, bHLHa48, SCX_HUMAN, SCXA, SCXB
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7RTU7
- Gene
- SCX
- Ensembl
- ENSG00000260428
- Chromosome
- 8
- Canonical length
- 201 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
201 residues, UniProt reviewed canonical sequence.
>Q7RTU7|SCX
1 MSFATLRPAP PGRYLYPEVS PLSEDEDRGS DSSGSDEKPC RVHAARCGLQ GARRRAGGRR
61 AGGGGPGGRP GREPRQRHTA NARERDRTNS VNTAFTALRT LIPTEPADRK LSKIETLRLA
121 SSYISHLGNV LLAGEACGDG QPCHSGPAFF HAARAGSPPP PPPPPPARDG ENTQPKQICT
181 FCLSNQRKLS KDRDRKTAIR SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 32 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 32 nTPM
- cerebellum: 23 nTPM
- blood vessel: 19 nTPM
- pituitary gland: 17 nTPM
- skeletal muscle: 13 nTPM
- heart muscle: 9.1 nTPM
Single-cell type
- epididymal principal cells: 218 nCPM
- smooth muscle cells: 69 nCPM
- innate lymphoid cells: 45 nCPM
- gonadotrophs: 33 nCPM
- thymic myoid cells: 23 nCPM
- medullary thymic epithelial cells: 22 nCPM
Immune cell
- memory B-cell: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebellum: 19 nTPM
- cerebral cortex: 17 nTPM
- pons: 16 nTPM
- medulla oblongata: 12 nTPM
- choroid plexus: 9.6 nTPM
- amygdala: 9.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- BMP signaling pathway
- cell differentiation
- cellular response to cAMP
- cellular response to follicle-stimulating hormone stimulus
- cellular response to mechanical stimulus
- cellular response to transforming growth factor beta stimulus
- chondrocyte differentiation
- collagen fibril organization
- deltoid tuberosity development
- developmental process
- DNA-templated transcription
- embryonic skeletal system development
- endochondral ossification
- face morphogenesis
- heart valve formation
- heart valve morphogenesis
- mesoderm formation
- negative regulation of apoptotic process
- negative regulation of DNA-templated transcription
- negative regulation of gene expression
- positive regulation of cartilage development
- positive regulation of cell population proliferation
- positive regulation of collagen biosynthetic process
- positive regulation of DNA-templated transcription
- positive regulation of gastrulation
- positive regulation of gene expression
- positive regulation of transcription by RNA polymerase II
- regulation of cartilage development
- regulation of transcription by RNA polymerase II
- sclerotome development
- Sertoli cell development
- Sertoli cell differentiation
- skeletal muscle cell differentiation
- tendon cell differentiation
- tendon development
- tissue homeostasis
- tendon formation
Molecular functions
- bHLH transcription factor binding
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- E-box binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCX as an antibody target. Whether an autoantibody or antibody against SCX could matter depends on whether native SCX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SCX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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