Seroatlas · Human Serome Atlas

MSC

Musculin

Also known as: ABF-1, bHLHa22, MUSC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60682
Gene: MSC
Ensembl: ENSG00000178860
Chromosome: 8
Canonical length: 206 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>O60682|MSC
     1  MSTGSVSDPE EMELRGLQRE YPVPASKRPP LRGVERSYAS PSDNSSAEEE DPDGEEERCA
    61  LGTAGSAEGC KRKRPRVAGG GGAGGSAGGG GKKPLPAKGS AAECKQSQRN AANARERARM
   121  RVLSKAFSRL KTSLPWVPPD TKLSKLDTLR LASSYIAHLR QLLQEDRYEN GYVHPVNLTW
   181  PFVVSGRPDS DTKEVSAANR LCGTTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 55 nTPM
heart muscle: 20 nTPM
urinary bladder: 19 nTPM
placenta: 15 nTPM
adipose tissue: 13 nTPM
lymph node: 11 nTPM

Single-cell type

melanocytes: 51 nCPM
peritubular myoid cells: 36 nCPM
myosatellite cells: 36 nCPM
hepatic stellate cells: 32 nCPM
leydig cells: 28 nCPM
pericytes: 27 nCPM

Immune cell

memory CD8 T-cell: 26 nTPM
T-reg: 13 nTPM
memory CD4 T-cell: 9.2 nTPM
naive CD8 T-cell: 8.7 nTPM
MAIT T-cell: 7.2 nTPM
memory B-cell: 6.9 nTPM

Brain region

hippocampal formation: 12 nTPM
cerebral cortex: 8.9 nTPM
medulla oblongata: 5.9 nTPM
white matter: 5.4 nTPM
amygdala: 4.6 nTPM
basal ganglia: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0.02
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSC as an antibody target. Whether an autoantibody or antibody against MSC could matter depends on whether native MSC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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