TCF21
Transcription factor 21
Also known as: bHLHa23, POD1, TCF21_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O43680
- Gene
- TCF21
- Ensembl
- ENSG00000118526
- Chromosome
- 6
- Canonical length
- 179 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>O43680|TCF21
1 MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ KGRGGLGKRR
61 KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT
121 LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ESDLKEVVTA SRLCGTTASLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TCF21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 198 nTPM
Expression across tissuesHPA
Tissue
- lung: 198 nTPM
- ovary: 192 nTPM
- placenta: 129 nTPM
- spleen: 96 nTPM
- heart muscle: 82 nTPM
- kidney: 80 nTPM
Single-cell type
- ovarian stromal cells: 241 nCPM
- podocytes: 125 nCPM
- peritubular myoid cells: 108 nCPM
- fibroblasts: 93 nCPM
- leydig cells: 75 nCPM
- pericytes: 71 nCPM
Immune cell
- basophil: 0.2 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 7.3 nTPM
- cerebral cortex: 4.8 nTPM
- hippocampal formation: 4.7 nTPM
- cerebellum: 2.2 nTPM
- medulla oblongata: 1.8 nTPM
- white matter: 1.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.52
- gnomAD pLI
- 0.83
- gnomAD missense Z
- 0.78
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- branching involved in ureteric bud morphogenesis
- branchiomeric skeletal muscle development
- bronchiole development
- developmental process
- diaphragm development
- embryonic digestive tract morphogenesis
- epithelial cell differentiation
- gland development
- glomerulus development
- kidney development
- lung alveolus development
- lung morphogenesis
- lung vasculature development
- metanephric glomerular capillary formation
- metanephric mesenchymal cell differentiation
- morphogenesis of a branching structure
- negative regulation of androgen receptor signaling pathway
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- reproductive structure development
- respiratory system development
- roof of mouth development
- Sertoli cell differentiation
- sex determination
- spleen development
- ureteric bud development
- vasculature development
Molecular functions
- bHLH transcription factor binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- E-box binding
- histone deacetylase binding
- nuclear androgen receptor binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TCF21 as an antibody target. Whether an autoantibody or antibody against TCF21 could matter depends on whether native TCF21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TCF21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TCF21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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