ASCL5
Achaete-scute homolog 5
Also known as: ASCL5_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- Q7RTU5
- Gene
- ASCL5
- Canonical length
- 278 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for ASCL5 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
278 residues, UniProt reviewed canonical sequence.
>Q7RTU5|ASCL5
1 MPMGAAERGA GPQSSAAPWA GSEKAAKRGP SKSWYPRAAA SDVTCPTGGD GADPKPGPFG
61 GGLALGPAPR GTMNNNFCRA LVDRRPLGPP SCMQLGVMPP PRQAPLPPAE PLGNVPFLLY
121 PGPAEPPYYD AYAGVFPYVP FPGAFGVYEY PFEPAFIQKR NERERQRVKC VNEGYARLRG
181 HLPGALAEKR LSKVETLRAA IRYIKYLQEL LSSAPDGSTP PASRGLPGTG PCPAPPATPR
241 PDRPGDGEAR APSSLVPESS ESSCFSPSPF LESEESWHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ASCL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 1.8 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 1.8 nTPM
- basal ganglia: 0.9 nTPM
- hypothalamus: 0.6 nTPM
- cerebral cortex: 0.5 nTPM
- skeletal muscle: 0.5 nTPM
- amygdala: 0.4 nTPM
Single-cell type
- thymic myoid cells: 6.8 nCPM
- cone photoreceptor cells: 2.1 nCPM
- pancreatic acinar cells: 1.7 nCPM
- enteric stem cells: 1.5 nCPM
- other brain neurons: 1.3 nCPM
- oligodendrocyte progenitor cells: 1.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 3.9 nTPM
- hippocampal formation: 3.7 nTPM
- basal ganglia: 3.3 nTPM
- cerebral cortex: 3.3 nTPM
- amygdala: 3.1 nTPM
- midbrain: 2.5 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ASCL5.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 1 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- LOBODONTIA
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ASCL5 as an antibody target. Whether an autoantibody or antibody against ASCL5 could matter depends on whether native ASCL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ASCL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ASCL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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