TCF23
Transcription factor 23
Also known as: bHLHa24, OUT, TCF23_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7RTU1
- Gene
- TCF23
- Ensembl
- ENSG00000163792
- Chromosome
- 2
- Canonical length
- 214 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nuclear speckles
OverviewNCBI Gene
The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]
Canonical amino-acid sequenceUniProt
214 residues, UniProt reviewed canonical sequence.
>Q7RTU1|TCF23
1 MSQRKARGPP AMPGVGHSQT QAKARLLPGA DRKRSRLSRT RQDPWEERSW SNQRWSRATP
61 GPRGTRAGGL ALGRSEASPE NAARERSRVR TLRQAFLALQ AALPAVPPDT KLSKLDVLVL
121 AASYIAHLTR TLGHELPGPA WPPFLRGLRY LHPLKKWPMR SRLYAGGLGY SDLDSTTAST
181 PSQRTRDAEV GSQVPGEADA LLSTTPLSPA LGDKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TCF23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- endometrium: 45 nTPM
- fallopian tube: 30 nTPM
- smooth muscle: 19 nTPM
- ovary: 18 nTPM
- cervix: 14 nTPM
- epididymis: 5.4 nTPM
Single-cell type
- peritubular myoid cells: 29 nCPM
- smooth muscle cells: 18 nCPM
- ovarian stromal cells: 12 nCPM
- leydig cells: 12 nCPM
- cardiomyocytes: 6.6 nCPM
- ocular epithelial cells: 4.6 nCPM
Immune cell
- basophil: 1.5 nTPM
- neutrophil: 0.9 nTPM
- memory B-cell: 0.3 nTPM
- naive B-cell: 0.3 nTPM
- naive CD4 T-cell: 0.3 nTPM
- NK-cell: 0.3 nTPM
Brain region
- cerebellum: 2.7 nTPM
- white matter: 2.6 nTPM
- cerebral cortex: 2.4 nTPM
- hippocampal formation: 2.3 nTPM
- pons: 2.3 nTPM
- amygdala: 2.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.76
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- decidualization
- developmental process
- muscle organ development
- negative regulation of muscle cell differentiation
- negative regulation of transcription by RNA polymerase II
- positive regulation of gene expression
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- transcription regulator inhibitor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TCF23 as an antibody target. Whether an autoantibody or antibody against TCF23 could matter depends on whether native TCF23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TCF23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TCF23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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