ASCL3
Achaete-scute homolog 3
Also known as: ASCL3_HUMAN, bHLHa42, HASH3, Sgn1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NQ33
- Gene
- ASCL3
- Ensembl
- ENSG00000176009
- Chromosome
- 11
- Canonical length
- 181 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
181 residues, UniProt reviewed canonical sequence.
>Q9NQ33|ASCL3
1 MMDNRGNSSL PDKLPIFPDS ARLPLTRSFY LEPMVTFHVH PEAPVSSPYS EELPRLPFPS
61 DSLILGNYSE PCPFSFPMPY PNYRGCEYSY GPAFTRKRNE RERQRVKCVN EGYAQLRHHL
121 PEEYLEKRLS KVETLRAAIK YINYLQSLLY PDKAETKNNP GKVSSMIATT SHHADPMFRI
181 VLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ASCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 9.5 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 9.5 nTPM
- thymus: 0.5 nTPM
- kidney: 0.2 nTPM
- retina: 0.2 nTPM
- cervix: 0.1 nTPM
- duodenum: 0.1 nTPM
Single-cell type
- salivary ionocytes: 1,561 nCPM
- respiratory ionocytes: 818 nCPM
- salivary basal cells: 35 nCPM
- mesothelial cells: 7.2 nCPM
- conjunctival goblet cells: 6.8 nCPM
- epicardial cells: 6.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 1.3 nTPM
- medulla oblongata: 1.1 nTPM
- white matter: 1 nTPM
- amygdala: 0.9 nTPM
- cerebral cortex: 0.9 nTPM
- pons: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.65
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.12
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- salivary gland development
- tissue homeostasis
- sensory epithelium regeneration
Molecular functions
- DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ASCL3 as an antibody target. Whether an autoantibody or antibody against ASCL3 could matter depends on whether native ASCL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ASCL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ASCL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...