TCF24
Transcription factor 24
Also known as: bHLHa25, TCF24_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7RTU0
- Gene
- TCF24
- Ensembl
- ENSG00000261787
- Chromosome
- 8
- Canonical length
- 167 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
167 residues, UniProt reviewed canonical sequence.
>Q7RTU0|TCF24
1 MDRGRPAGSP LSASAEPAPL AAAIRDSRPG RTGPGPAGPG GGSRSGSGRP AAANAARERS
61 RVQTLRHAFL ELQRTLPSVP PDTKLSKLDV LLLATTYIAH LTRSLQDDAE APADAGLGAL
121 RGDGYLHPVK KWPMRSRLYI GATGQFLKHS VSGEKTNHDN TPTDSQPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TCF24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 1.4 nTPM
Expression across tissuesHPA
Tissue
- testis: 1.4 nTPM
- kidney: 1 nTPM
- heart muscle: 0.9 nTPM
- fallopian tube: 0.4 nTPM
- skeletal muscle: 0.3 nTPM
- stomach: 0.2 nTPM
Single-cell type
- cardiomyocytes: 72 nCPM
- distal convoluted tubule cells: 65 nCPM
- early primary spermatocytes: 16 nCPM
- ependymal cells: 14 nCPM
- papillary tip epithelial cells: 8.2 nCPM
- myonuclei: 7.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 1.9 nTPM
- midbrain: 1.8 nTPM
- pons: 1.4 nTPM
- spinal cord: 1.3 nTPM
- white matter: 1.2 nTPM
- amygdala: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0.03
- gnomAD missense Z
- -0.11
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TCF24 as an antibody target. Whether an autoantibody or antibody against TCF24 could matter depends on whether native TCF24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TCF24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TCF24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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