TCF15

Protein identityUniProt · HPA

UniProt accession

Q12870

Gene

TCF15

Ensembl

ENSG00000125878

Chromosome

20

Canonical length

199 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q12870|TCF15
     1  MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG PGPGGGRRAG
    61  GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP TEPVDRKLSK IETVRLASSY
   121  IAHLANVLLL GDSADDGQPC FRAAGSAKGA VPAAADGGRQ PRSICTFCLS NQRKGGGRRD
   181  LGGSCLKVRG VAPLRGPRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCF15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

44 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.3

gnomAD pLI

0.52

gnomAD missense Z

1.13

DepMap mean gene effect

0.16

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• developmental process
• ear development
• establishment of epithelial cell apical/basal polarity
• mesenchymal to epithelial transition
• mesoderm development
• muscle organ morphogenesis
• negative regulation of hematopoietic stem cell differentiation
• neuromuscular process controlling posture
• paraxial mesoderm development
• positive regulation of stem cell differentiation
• positive regulation of transcription by RNA polymerase II
• post-anal tail morphogenesis
• regulation of extracellular matrix organization
• regulation of transcription by RNA polymerase II
• respiratory system process
• skeletal system morphogenesis
• somitogenesis
• stem cell population maintenance

Molecular functions

• bHLH transcription factor binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• E-box binding
• protein dimerization activity
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• chromatin
• nucleus
• RNA polymerase II transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Myc-type, basic helix-loop-helix (bHLH) domain
• Helix-loop-helix DNA-binding domain superfamily
• E-box Binding Transcriptional Regulators
• Helix-loop-helix DNA-binding domain

KeywordsUniProt

• Activator
• Developmental protein
• Differentiation
• DNA-binding
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TCF15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MEOX2