Seroatlas · Human Serome Atlas

CALML6

Calmodulin-like protein 6

Also known as: CAGLP, CALL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD86
Gene: CALML6
Ensembl: ENSG00000169885
Chromosome: 1
Canonical length: 181 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>Q8TD86|CALML6
     1  MGLQQEISLQ PWCHHPAESC QTTTDMTERL SAEQIKEYKG VFEMFDEEGN GEVKTGELEW
    61  LMSLLGINPT KSELASMAKD VDRDNKGFFN CDGFLALMGV YHEKAQNQES ELRAAFRVFD
   121  KEGKGYIDWN TLKYVLMNAG EPLNEVEAEQ MMKEADKDGD RTIDYEEFVA MMTGESFKLI
   181  Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALML6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 145 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 145 nTPM
tongue: 102 nTPM
esophagus: 6.6 nTPM
salivary gland: 3.5 nTPM
liver: 2.3 nTPM
pancreas: 1.7 nTPM

Single-cell type

thymic myoid cells: 30 nCPM
pdcs: 1.9 nCPM
basal prostatic cells: 1.8 nCPM
myonuclei: 1.6 nCPM
pancreatic acinar cells: 1.4 nCPM
vascular smooth muscle cells: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.6 nTPM
cerebral cortex: 0.5 nTPM
cerebellum: 0.4 nTPM
white matter: 0.4 nTPM
amygdala: 0.3 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule cytoskeleton organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALML6 as an antibody target. Whether an autoantibody or antibody against CALML6 could matter depends on whether native CALML6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALML6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALML6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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