Seroatlas · Human Serome Atlas

MYL6

Myosin light polypeptide 6

Also known as: ESMLC, MLC1SM, MLC3NM, MYL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60660
Gene: MYL6
Ensembl: ENSG00000092841
Chromosome: 12
Canonical length: 151 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>P60660|MYL6
     1  MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM
    61  NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM
   121  TEEEVEMLVA GHEDSNGCIN YEAFVRHILS G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 5,588 nTPM

Expression across tissuesHPA

Tissue

colon: 5,588 nTPM
blood vessel: 4,620 nTPM
smooth muscle: 3,928 nTPM
urinary bladder: 3,150 nTPM
endometrium: 2,761 nTPM
seminal vesicle: 2,738 nTPM

Single-cell type

megakaryocytes: 10,292 nCPM
esophageal apical cells: 7,144 nCPM
platelets: 6,270 nCPM
decidual stromal cells: 6,127 nCPM
smooth muscle cells: 5,059 nCPM
esophageal suprabasal cells: 4,395 nCPM

Immune cell

total PBMC: 14,793 nTPM
eosinophil: 13,347 nTPM
basophil: 11,505 nTPM
neutrophil: 8,492 nTPM
non-classical monocyte: 6,564 nTPM
plasmacytoid DC: 5,181 nTPM

Brain region

thalamus: 447 nTPM
medulla oblongata: 443 nTPM
choroid plexus: 433 nTPM
pons: 380 nTPM
white matter: 364 nTPM
hypothalamus: 356 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYL6 as an antibody target. Whether an autoantibody or antibody against MYL6 could matter depends on whether native MYL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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