Seroatlas · Human Serome Atlas

CALML3

Calmodulin-like protein 3

Also known as: CALL3_HUMAN, CLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P27482
Gene: CALML3
Ensembl: ENSG00000178363
Chromosome: 10
Canonical length: 149 aa
Protein class: Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>P27482|CALML3
     1  MADQLTEEQV TEFKEAFSLF DKDGDGCITT RELGTVMRSL GQNPTEAELR DMMSEIDRDG
    61  NGTVDFPEFL GMMARKMKDT DNEEEIREAF RVFDKDGNGF VSAAELRHVM TRLGEKLSDE
   121  EVDEMIRAAD TDGDGQVNYE EFVRVLVSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALML3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 823 nTPM

Expression across tissuesHPA

Tissue

esophagus: 823 nTPM
vagina: 318 nTPM
cervix: 307 nTPM
skin: 278 nTPM
salivary gland: 190 nTPM
thymus: 74 nTPM

Single-cell type

esophageal suprabasal cells: 5,508 nCPM
esophageal apical cells: 4,924 nCPM
esophageal basal cells: 1,689 nCPM
suprabasal keratinocytes: 744 nCPM
salivary duct cells: 478 nCPM
salivary ionocytes: 296 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.7 nTPM
thalamus: 2.1 nTPM
medulla oblongata: 1.3 nTPM
midbrain: 1.1 nTPM
hypothalamus: 1 nTPM
amygdala: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: 0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALML3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALML3 as an antibody target. Whether an autoantibody or antibody against CALML3 could matter depends on whether native CALML3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALML3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALML3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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