Seroatlas · Human Serome Atlas

CALML4

Calmodulin-like protein 4

Also known as: CALL4_HUMAN, MGC4809, NY-BR-20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GE6
Gene: CALML4
Ensembl: ENSG00000129007
Chromosome: 15
Canonical length: 196 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables myosin head/neck binding activity. Involved in brush border assembly. Located in microvillus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q96GE6|CALML4
     1  MAAEHLLPGP PPSLADFRLE AGGKGTERGS GSSKPTGSSR GPRMAKFLSQ DQINEYKECF
    61  SLYDKQQRGK IKATDLMVAM RCLGASPTPG EVQRHLQTHG IDGNGELDFS TFLTIMHMQI
   121  KQEDPKKEIL LAMLMVDKEK KGYVMASDLR SKLTSLGEKL THKEVDDLFR EADIEPNGKV
   181  KYDEFIHKIT LPGRDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALML4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

duodenum: 36 nTPM
small intestine: 29 nTPM
rectum: 29 nTPM
choroid plexus: 27 nTPM
colon: 27 nTPM
kidney: 12 nTPM

Single-cell type

colonocytes: 21 nCPM
fallopian tube ciliated cells: 18 nCPM
enterocytes: 18 nCPM
choroid plexus epithelial cells: 16 nCPM
epididymal efferent duct ciliated cells: 15 nCPM
endometrial ciliated cells: 14 nCPM

Immune cell

non-classical monocyte: 66 nTPM
intermediate monocyte: 57 nTPM
classical monocyte: 31 nTPM
myeloid DC: 18 nTPM
neutrophil: 18 nTPM
total PBMC: 9.1 nTPM

Brain region

choroid plexus: 14 nTPM
cerebellum: 3.2 nTPM
cerebral cortex: 2.6 nTPM
white matter: 2.1 nTPM
hippocampal formation: 1.9 nTPM
thalamus: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -0.7
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALML4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALML4 as an antibody target. Whether an autoantibody or antibody against CALML4 could matter depends on whether native CALML4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALML4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALML4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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