Seroatlas · Human Serome Atlas

CETN3

Centrin-3

Also known as: CEN3, CETN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15182
Gene
CETN3
Ensembl
ENSG00000153140
Chromosome
5
Canonical length
167 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Basal body

OverviewNCBI Gene

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>O15182|CETN3
     1  MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD
    61  VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL
   121  RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEINQEEFI AIMTGDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CETN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
122 nTPM

Expression across tissuesHPA

Tissue

  • testis: 122 nTPM
  • retina: 33 nTPM
  • ovary: 29 nTPM
  • choroid plexus: 26 nTPM
  • parathyroid gland: 23 nTPM
  • breast: 23 nTPM

Single-cell type

  • late primary spermatocytes: 969 nCPM
  • early primary spermatocytes: 322 nCPM
  • extravillous trophoblasts: 86 nCPM
  • megakaryocytes: 80 nCPM
  • cytotrophoblasts: 77 nCPM
  • esophageal apical cells: 77 nCPM

Immune cell

  • plasmacytoid DC: 31 nTPM
  • memory B-cell: 27 nTPM
  • naive B-cell: 22 nTPM
  • naive CD4 T-cell: 21 nTPM
  • basophil: 20 nTPM
  • NK-cell: 17 nTPM

Brain region

  • white matter: 34 nTPM
  • medulla oblongata: 23 nTPM
  • basal ganglia: 21 nTPM
  • hypothalamus: 20 nTPM
  • midbrain: 20 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.39
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CETN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CETN3 as an antibody target. Whether an autoantibody or antibody against CETN3 could matter depends on whether native CETN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CETN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CETN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CETN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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