Seroatlas · Human Serome Atlas

TNNC2

Troponin C, skeletal muscle

Also known as: CFAP85, FAP85, TNNC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P02585
Gene: TNNC2
Ensembl: ENSG00000101470
Chromosome: 20
Canonical length: 160 aa
Protein class: Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>P02585|TNNC2
     1  MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII
    61  EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF
   121  RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNNC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 28,518 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 28,518 nTPM
tongue: 7,540 nTPM
salivary gland: 177 nTPM
esophagus: 121 nTPM
prostate: 42 nTPM
basal ganglia: 9.9 nTPM

Single-cell type

thymic myoid cells: 2,524 nCPM
enterocytes: 316 nCPM
myonuclei: 191 nCPM
colonocytes: 133 nCPM
salivary duct cells: 131 nCPM
platelets: 123 nCPM

Immune cell

total PBMC: 8.7 nTPM
memory B-cell: 5.3 nTPM
naive B-cell: 4.7 nTPM
T-reg: 4 nTPM
neutrophil: 2 nTPM
eosinophil: 1.4 nTPM

Brain region

basal ganglia: 4.3 nTPM
cerebral cortex: 3.9 nTPM
white matter: 3.9 nTPM
cerebellum: 3.3 nTPM
hypothalamus: 2.5 nTPM
amygdala: 2.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNNC2.

Disease | AllUniProt

Conditions TNNC2 is implicated in, by any mechanism.

Congenital myopathy 15 (CMYO15) MIM:620161

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 14 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Congenital myopathy 15

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0.02
gnomAD missense Z: 1.2
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNNC2 as an antibody target. Whether an autoantibody or antibody against TNNC2 could matter depends on whether native TNNC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNNC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNNC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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