MYL6B
Myosin light chain 6B
Also known as: MLC1SA, MYL6B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P14649
- Gene
- MYL6B
- Ensembl
- ENSG00000196465
- Chromosome
- 12
- Canonical length
- 208 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
OverviewNCBI Gene
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Canonical amino-acid sequenceUniProt
208 residues, UniProt reviewed canonical sequence.
>P14649|MYL6B
1 MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP PVDLSKVVIE
61 FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP TNAEVLKVLG NPKSDELKSR
121 RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF RVFDKEGNGK VMGAELRHVL TTLGEKMTEE
181 EVETVLAGHE DSNGCINYEA FLKHILSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MYL6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 640 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 640 nTPM
- tongue: 611 nTPM
- basal ganglia: 176 nTPM
- amygdala: 174 nTPM
- cerebral cortex: 168 nTPM
- testis: 134 nTPM
Single-cell type
- late spermatids: 2,216 nCPM
- late primary spermatocytes: 347 nCPM
- early spermatids: 332 nCPM
- epididymal efferent duct absorptive cells: 248 nCPM
- sertoli cells: 136 nCPM
- esophageal basal cells: 132 nCPM
Immune cell
- plasmacytoid DC: 30 nTPM
- T-reg: 20 nTPM
- memory B-cell: 11 nTPM
- myeloid DC: 10 nTPM
- total PBMC: 6 nTPM
- memory CD4 T-cell: 5.6 nTPM
Brain region
- hypothalamus: 97 nTPM
- cerebral cortex: 97 nTPM
- basal ganglia: 93 nTPM
- amygdala: 91 nTPM
- hippocampal formation: 90 nTPM
- thalamus: 88 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.51
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MYL6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MYL6B as an antibody target. Whether an autoantibody or antibody against MYL6B could matter depends on whether native MYL6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MYL6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MYL6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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