Three Amino acid Loop Extension (TALE) homeobox
IPR050224
Definition
The TALE homeobox family is characterized by a conserved DNA-binding homeodomain, playing pivotal roles in developmental processes across diverse organisms. Members of this family function as transcription factors, regulating gene expression patterns critical for morphogenesis, organ development, and cellular differentiation. They are involved in meristem maintenance, leaf and shoot formation, floral development, and embryogenesis. Some proteins within this family bind specific DNA sequences, such as 5'-TGAC-3', to modulate transcriptional activities. They also form heterodimeric complexes with other homeobox proteins, enhancing DNA-binding specificity and transcriptional regulation. The TALE homeobox proteins are further implicated in hematopoiesis, vascular patterning, and neural development, with some acting as transcriptional activators or repressors in response to retinoid signaling. The family includes several subfamilies like KNOX, MEIS, PBX, and TGIF, each with distinct but overlapping functions contributing to their versatile roles in development and differentiation.
15 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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