TGIF2LX
Homeobox protein TGIF2LX
Also known as: TF2LX_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IUE1
- Gene
- TGIF2LX
- Ensembl
- ENSG00000153779
- Chromosome
- X
- Canonical length
- 241 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expression suggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
241 residues, UniProt reviewed canonical sequence.
>Q8IUE1|TGIF2LX
1 MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK KKRKGNLPAE
61 SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLQISNW FINARRRILP DMLQQRRNDP
121 IIGHKTGKDA HATHLQSTEA SVPAKSGPSG PDNVQSLPLW PLPKGQMSRE KQPDPESAPS
181 QKLTGIAQPK KKVKVSVTSP SSPELVSPEE HADFSSFLLL VDAAVQRAAE LELEKKQEPN
241 PLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TGIF2LX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 8.6 nTPM
Expression across tissuesHPA
Tissue
- testis: 8.6 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 63 nCPM
- early spermatids: 62 nCPM
- late primary spermatocytes: 49 nCPM
- sertoli cells: 1.1 nCPM
- undifferentiated spermatogonia: 0.8 nCPM
- differentiating spermatogonia: 0.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.88
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TGIF2LX as an antibody target. Whether an autoantibody or antibody against TGIF2LX could matter depends on whether native TGIF2LX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TGIF2LX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TGIF2LX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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