Seroatlas · Human Serome Atlas

PBX4

Pre-B-cell leukemia transcription factor 4

Also known as: PBX4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYU1
Gene: PBX4
Ensembl: ENSG00000105717
Chromosome: 19
Canonical length: 374 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q9BYU1|PBX4
     1  MAAPPRPAPS PPAPRRLDTS DVLQQIMAIT DQSLDEAQAR KHALNCHRMK PALFSVLCEI
    61  KEKTVVSIRG IQDEDPPDAQ LLRLDNMLLA EGVCRPEKRG RGGAVARAGT ATPGGCPNDN
   121  SIEHSDYRAK LSQIRQIYHS ELEKYEQACR EFTTHVTNLL QEQSRMRPVS PKEIERMVGA
   181  IHGKFSAIQM QLKQSTCEAV MTLRSRLLDA RRKRRNFSKQ ATEVLNEYFY SHLNNPYPSE
   241  EAKEELARKG GLTISQVSNW FGNKRIRYKK NMGKFQEEAT IYTGKTAVDT TEVGVPGNHA
   301  SCLSTPSSGS SGPFPLPSAG DAFLTLRTLA SLQPPPGGGC LQSQAQGSWQ GATPQPATAS
   361  PAGDPGSINS STSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PBX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 3.6 nTPM
testis: 3.5 nTPM
lymph node: 1.1 nTPM
hypothalamus: 1 nTPM
thymus: 0.9 nTPM
skin: 0.8 nTPM

Single-cell type

t-cells: 337 nCPM
early primary spermatocytes: 81 nCPM
platelets: 78 nCPM
retinal pigment epithelial cells: 73 nCPM
foveolar cells: 72 nCPM
thyrotrophs: 71 nCPM

Immune cell

T-reg: 3.1 nTPM
memory CD8 T-cell: 1.9 nTPM
gdT-cell: 1.7 nTPM
MAIT T-cell: 1.7 nTPM
memory CD4 T-cell: 1.2 nTPM
naive CD4 T-cell: 1.2 nTPM

Brain region

hypothalamus: 1.6 nTPM
thalamus: 1.6 nTPM
cerebral cortex: 1 nTPM
amygdala: 0.9 nTPM
basal ganglia: 0.9 nTPM
hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PBX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PBX4 as an antibody target. Whether an autoantibody or antibody against PBX4 could matter depends on whether native PBX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PBX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PBX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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