TGIF2LY
Homeobox protein TGIF2LY
Also known as: TF2LY_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IUE0
- Gene
- TGIF2LY
- Ensembl
- ENSG00000176679
- Chromosome
- Y
- Canonical length
- 185 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggesting that this protein may act as a regulator of TGIF2LX. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
185 residues, UniProt reviewed canonical sequence.
>Q8IUE0|TGIF2LY
1 MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK KKRKGNLPAE
61 SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW FINARRRILP DMLQQRRNDP
121 IIGHKTGKDA HATHLQSTEA SVPAKSGPVV QTMYKACPCG PCQRARCQER SNQIRSRPLA
181 RSSPELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TGIF2LY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 3.7 nTPM
Expression across tissuesHPA
Tissue
- testis: 3.7 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 21 nCPM
- late primary spermatocytes: 21 nCPM
- early spermatids: 9.3 nCPM
- undifferentiated spermatogonia: 0.4 nCPM
- differentiating spermatogonia: 0.1 nCPM
- early primary spermatocytes: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about TGIF2LY.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 1 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Male infertility with azoospermia or oligozoospermia due to single gene mutation
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.28
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TGIF2LY as an antibody target. Whether an autoantibody or antibody against TGIF2LY could matter depends on whether native TGIF2LY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TGIF2LY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TGIF2LY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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