MEIS2

Protein identityUniProt · HPA

UniProt accession

O14770

Gene

MEIS2

Ensembl

ENSG00000134138

Chromosome

15

Canonical length

477 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>O14770|MEIS2
     1  MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV
    61  MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN
   121  EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK
   181  GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH
   241  ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT
   301  HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS
   361  PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR
   421  HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

45 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MEIS2.

Disease | AllUniProt

Conditions MEIS2 is implicated in, by any mechanism.

• Cleft palate, cardiac defects, and impaired intellectual development (CPCMR) MIM:600987

Disease | GeneticClinVar

45 pathogenic / likely-pathogenic of 237 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cardiac malformation, cleft lip/palate, microcephaly, and digital anomalies
• Inborn genetic diseases
• MEIS2-related disorder
• Cleft palate
• Syndromic intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.18

gnomAD pLI

1

gnomAD missense Z

2.46

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ morphogenesis
• brain development
• embryonic pattern specification
• eye development
• negative regulation of myeloid cell differentiation
• negative regulation of transcription by RNA polymerase II
• pancreas development
• positive regulation of cardiac muscle myoblast proliferation
• positive regulation of cell population proliferation
• positive regulation of mitotic cell cycle
• positive regulation of transcription by RNA polymerase II
• response to growth factor
• response to mechanical stimulus
• visual learning

Molecular functions

• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• transcription factor binding

Cellular components

• chromatin
• nucleus
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• KN homeodomain
• Homedomain-like superfamily
• Homeobox protein PKNOX/Meis, N-terminal
• Three Amino acid Loop Extension (TALE) homeobox
• Homeobox KN domain
• TALE/MEIS homeobox family N-terminal domain

KeywordsUniProt

• Activator
• Cytoplasm
• Developmental protein
• DNA-binding
• Homeobox
• Intellectual disability
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of MEIS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HOXA13
• KLF4
• SP1
• SP3
• TLX1
• PBX1