Seroatlas · Human Serome Atlas

MEIS3

Homeobox protein Meis3

Also known as: DKFZp547H236, MEIS3_HUMAN, MRG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99687
Gene: MEIS3
Ensembl: ENSG00000105419
Chromosome: 19
Canonical length: 375 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q99687|MEIS3
     1  MARRYDELPH YPGIVDGPAA LASFPETVPA VPGPYGPHRP PQPLPPGLDS DGLKREKDEI
    61  YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPPGGDVC SSDSFNEDIA AFAKQVRSER
   121  PLFSSNPELD NLMIQAIQVL RFHLLELEKV HDLCDNFCHR YITCLKGKMP IDLVIEDRDG
   181  GCREDFEDYP ASCPSLPDQN NMWIRDHEDS GSVHLGTPGP SSGGLASQSG DNSSDQGDGL
   241  DTSVASPSSG GEDEDLDQER RRNKKRGIFP KVATNIMRAW LFQHLSHPYP SEEQKKQLAQ
   301  DTGLTILQVN NWFINARRRI VQPMIDQSNR TGQGAAFSPE GQPIGGYTET QPHVAVRPPG
   361  SVGMSLNLEG EWHYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

amygdala: 115 nTPM
cerebral cortex: 108 nTPM
hippocampal formation: 87 nTPM
endometrium: 80 nTPM
fallopian tube: 62 nTPM
cervix: 41 nTPM

Single-cell type

late spermatids: 102 nCPM
early spermatids: 81 nCPM
retinal amacrine cells: 62 nCPM
smooth muscle cells: 59 nCPM
brain excitatory neurons: 58 nCPM
other brain neurons: 44 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 132 nTPM
amygdala: 124 nTPM
hippocampal formation: 121 nTPM
basal ganglia: 107 nTPM
hypothalamus: 86 nTPM
white matter: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEIS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HOXA13

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEIS3 as an antibody target. Whether an autoantibody or antibody against MEIS3 could matter depends on whether native MEIS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEIS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEIS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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