MEIS1

Protein identityUniProt · HPA

UniProt accession

O00470

Gene

MEIS1

Ensembl

ENSG00000143995

Chromosome

2

Canonical length

390 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>O00470|MEIS1
     1  MAQRYDDLPH YGGMDGVGIP STMYGDPHAA RSMQPVHHLN HGPPLHSHQY PHTAHTNAMA
    61  PSMGSSVNDA LKRDKDAIYG HPLFPLLALI FEKCELATCT PREPGVAGGD VCSSESFNED
   121  IAVFAKQIRA EKPLFSSNPE LDNLMIQAIQ VLRFHLLELE KVHELCDNFC HRYISCLKGK
   181  MPIDLVIDDR EGGSKSDSED ITRSANLTDQ PSWNRDHDDT ASTRSGGTPG PSSGGHTSHS
   241  GDNSSEQGDG LDNSVASPST GDDDDPDKDK KRHKKRGIFP KVATNIMRAW LFQHLTHPYP
   301  SEEQKKQLAQ DTGLTILQVN NWFINARRRI VQPMIDQSNR AVSQGTPYNP DGQPMGGFVM
   361  DGQQHMGIRA PGPMSGMGMN MGMEGQWHYM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

83 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MEIS1.

Disease | AllUniProt

Conditions MEIS1 is implicated in, by any mechanism.

• Restless legs syndrome 7 (RLS7) MIM:612853

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.14

gnomAD pLI

1

gnomAD missense Z

3.3

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• animal organ morphogenesis
• brain development
• cell growth involved in cardiac muscle cell development
• definitive hemopoiesis
• embryonic pattern specification
• eye development
• hemopoiesis
• lens morphogenesis in camera-type eye
• locomotory behavior
• megakaryocyte development
• negative regulation of myeloid cell differentiation
• negative regulation of neuron differentiation
• positive regulation of cell population proliferation
• positive regulation of transcription by RNA polymerase II

Molecular functions

• chromatin binding
• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• chromatin
• nucleus
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• KN homeodomain
• Homedomain-like superfamily
• Homeobox protein PKNOX/Meis, N-terminal
• Three Amino acid Loop Extension (TALE) homeobox
• Homeobox KN domain
• TALE/MEIS homeobox family N-terminal domain

KeywordsUniProt

• Activator
• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Transcription

InteractionsUniProt · HPA

Protein binding partners of MEIS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TLX1
• HOXA13
• PBX1