SPATA31
IPR039509
Definition
This entry represents a domain found in SPATA31. This domain is often found associated with [interpro:IPR027970]. Spermatogenesis-associated protein 3 (SPATA3), also known as Aep1, is a testis-specific protein primarily expressed during the haploid stage of spermatogenesis, from round spermatids to mature sperm. SPATA3 localizes to the acrosome region of developing spermatids and plays a role in spermiogenesis. While its precise function remains unclear, SPATA3 is involved in sperm formation and function. Deletion of the Spata3 gene in mice leads to in vitro fertility defects and ultrastructural anomalies in sperm [[cite:PMID:33669425], [cite:PMID:16924657]]. SPATA3 has been found to interact with beta-actin and syntaxin 1 in vitro PMID:20850414.
13 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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