Seroatlas · Human Serome Atlas

SPATA31F1

Protein SPATA31F1

Also known as: C9orf144B, FAM205A, S31F1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZU69
Gene: SPATA31F1
Ensembl: ENSG00000205108
Chromosome: 9
Canonical length: 1335 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center,Plasma membrane,Acrosome,Mid piece,Principal piece

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1335 residues, UniProt reviewed canonical sequence.

>Q6ZU69|SPATA31F1
     1  MLSPTFVLWE VGYPLYIYGS IFIVIVIIWQ VKRSHHELSS EPKRSCCRCH QKVRQRARDA
    61  ASTARRRSRE EAEKPQKLLS IIKSQGWLPL ERSVRRILCA DPCCQICNSV ALEIQQLLVG
   121  ENNQISLTLS GPLQGSSCLE MLSTSSMSLD QSLEFHSWHT RELSLSSVTP TLSQLTDQKS
   181  LTQSAAQSTY ADGIQDYWAD HLQLGQEFQV PDVLRGPNTI ASSRIEKPRA PLNQEEMTQS
   241  NPSLVQGNQG QHHLNSQVSL LSLNPETLNR MHPMALHMVL PAHLPFLSPE VLRLLEVHVK
   301  KWMHFQRWGL PRRVEESLRQ LMPNPPLYYQ PGNDQPVSFN LKNTPQVSLH RFETISLQTW
   361  CSCVAGQPIQ TFWVSEWSTM NPEQRHHCQQ TPNPMALALP SPALKALSGP HPQSGGQDND
   421  SGSDLQQKYS QLFCGLPSLH SESLVATFMG SQGLPKIENV PKPPLKDPFL FNELSFPQLL
   481  PKTSPQSAPP SSPLSPNWMS PSDHQRAQIN VPFLTLAEYE ALEWHLLQRQ LQLQWGWPAA
   541  LQRSQHTQCL MQHEPCGKAQ SPETTTASQT GKSISVLTRE LLFFPEHARK LLEFHIQKQL
   601  IRHRWGLPQK IQQSIQLLLT STDQQTVSSS STALANVSIP QPVALEANGA CDVLSPIAAP
   661  VSIPRPHLLT QVKAILQSHI DSKCGQIHQG KIPACVHRSW DCRISGVLAV APFPCIPESQ
   721  FLELQTASDP DLHHKVMPWM PTALDQQQQA LPGTVTEHPK LLRVLSVEAI EKLETTLRHK
   781  HLAFLSGLPA LYYVALPRAL APAVTSQSVI TEMEPSPVEI PAEPLIQMVS FEEQCISLGP
   841  CPQGNNESCT DVAKEFQPAV PVKGTMETLP LESQTHPTSP HSLQTHILTK LNFHLRKKVL
   901  EIQWGIPIRA RKSREQTVAA PENISTQKSL ESLNHQGETL LQELPIPPDT LPAPNPEGVH
   961  LKEQLANDLK AVQQNQKQSN SKAVPQGSAH SVSKISQPSG DMTEAHMPCV QVEANVNKPS
  1021  LEEPCGPEPQ SPSKSKDPAH VPMLAGNRED PEETKAARDH REGDAGFGRS STREERRPAE
  1081  DQRPAGMLPN KTPRGSWRWS RSFHLADPCQ HSPQHHPQLK LPQLPPRVPG EKESEKDLQD
  1141  SQTKLTVILE PATIPENAQT VLPQASQGQP FLSQPTQAKP LQGQTLQGQV LHGLVMPVHA
  1201  QKKPSLTESS FRNKIKCFLQ HINPKTKGKG HEDSMFSAAA KVAKTRKENV AKSLAPAKSP
  1261  VGRSKTEKPT GCSKAQSRPA QKLVGPAFLD GPQSLDDKLR LHSRQPGSAS ALGYPRHCPR
  1321  HCPREACANK PGHPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31F1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 171 nCPM
late primary spermatocytes: 53 nCPM
late spermatids: 22 nCPM
epicardial cells: 4.5 nCPM
sertoli cells: 2.6 nCPM
peritubular myoid cells: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 1.1 nTPM
pons: 0.9 nTPM
amygdala: 0.8 nTPM
basal ganglia: 0.8 nTPM
cerebral cortex: 0.8 nTPM
choroid plexus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.32
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31F1 as an antibody target. Whether an autoantibody or antibody against SPATA31F1 could matter depends on whether native SPATA31F1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31F1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31F1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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