Seroatlas · Human Serome Atlas

SPATA31C2

Spermatogenesis-associated protein 31C2

Also known as: DKFZP434M131, FAM75C2, S31C2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B4DYI2
Gene: SPATA31C2
Ensembl: ENSG00000177910
Chromosome: 9
Canonical length: 1134 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1134 residues, UniProt reviewed canonical sequence.

>B4DYI2|SPATA31C2
     1  MENLPFPLKL LSASSLNTPS STPWVLDIFL TLVFALGFFF LLLPYFSYLR CDNPPSPSPK
    61  KRKRHLVSQR PAGRRGRPRG RMKNHSLRAC RECPRGLEET WDLLSQLQSL LGPHLEKGDF
   121  GQLSGPDPPG EVGKRTPDGA SRSSHEPTED AAPIVSPLAS PDPRTKHPQD LASTPPPGPM
   181  TTSVSSLSAS QPPEPSLLLE HPSPEPPALF PHPPRTPDPL ACSPPPPKGF TPPPLRDSTL
   241  LTPSHCDSVA LPLDTVPQSL SPREDLAASV PGISGLGGSN SQVSALSWSQ ETTKTWCVFN
   301  SSVQQDHLSR QRDTTMSPLL FQAQPLSHLE PESQPFISST PQFWPTPMAQ AEAQAHLQSS
   361  FPVLSPAFLS PMKNTGVACP ASQNKVQALS LPETQHPERP LLKKQLEGGL ALPSRVQKSQ
   421  DVFSVSTPNL PQERLTSILP ENFPVSPELW RQLEQHMGQR GRIQESLDLM QLQDELPGTS
   481  QAKGKPRPWQ SSTSTGESSK EAQTVKFQLE RDPCPHLGQI LGETPQNLSR GMESFPGKVL
   541  GATSEESERN LRKPLRSDSG SDLLRRTERN HIENILKAHM SRKLGQTNEG LIPVSVRRSW
   601  LAVNQAFPVS NTHVKTSNLA APKSRKACVN TAQVLSFLEP CTQQVLGAHI VRFWAKHRWG
   661  LPLRVLKPIQ CFQLEKVSSL SLIQLAGPSS DTCESGAGSK VEVATFLGEP PMASLRKQVL
   721  TKPSVHMPER LQASSPACKQ FQRAPRGIPS SNDHGSLKAP TAGQEGRWPS KPLTYSLTGS
   781  TQQSRSLGAQ SSRAGETREA VPQPTVPLGT CMRANLQATS EDVRGFKAPG ASKSSLLPRM
   841  SVSQDPRKLC LMEEAVSEFE PGKATKSETQ PQVSATVVLL PDGQASVVPH ASENLASQVP
   901  QGHLQSMPTG NMQASQELCD LMSARRSNMG HKEPRNPNCQ GSCKSQSPMF PPTHKRENSR
   961  KPNLEKHEEM FQGLRTPQLT PGRKTEDTRQ NEGVQLLPSK KQPPSISHFG ENIKQFFQTI
  1021  FSKKERKPAP VTAESQKTVK NRSCVYGSSA EAERLMTAVG QILEENMSLC HARHASKVNQ
  1081  QRQQFQAPVC GFPCNHRHPF YSEHSRMLSY AASSQQATLK NQSRPNRDRQ IRDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

epididymis: 22 nTPM
testis: 7.3 nTPM
fallopian tube: 0.2 nTPM
cervix: 0.1 nTPM
endometrium: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

early spermatids: 35 nCPM
late primary spermatocytes: 16 nCPM
late spermatids: 6.7 nCPM
epididymal principal cells: 5.9 nCPM
epididymal basal cells: 0.5 nCPM
undifferentiated spermatogonia: 0.4 nCPM

Immune cell

T-reg: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hippocampal formation: 13 nTPM
cerebral cortex: 1 nTPM
white matter: 0.5 nTPM
amygdala: 0.4 nTPM
thalamus: 0.3 nTPM
basal ganglia: 0.1 nTPM

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31C2 as an antibody target. Whether an autoantibody or antibody against SPATA31C2 could matter depends on whether native SPATA31C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31C2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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