Seroatlas · Human Serome Atlas

SPATA31D3

Spermatogenesis-associated protein 31D3

Also known as: FAM75D3, FLJ44082, S31D3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C874
Gene: SPATA31D3
Ensembl: ENSG00000186788
Chromosome: 9
Canonical length: 917 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

917 residues, UniProt reviewed canonical sequence.

>P0C874|SPATA31D3
     1  MENILCFLNS YTETGLSPDS HCLDIDLNFI CLSGLGLFIL YLFYMVLTLY SSPTEKNNDT
    61  QKHQGRARRK RKSVTFKDRK SLQKEAEEER KLHSFLKSFG PPVSCSPLGQ HHDTTLFRRL
   121  LCPDPVCRVC NRATADIQRL LSWESLKDAA PSVSPLASSA SGAESSFTLA STPSATTPED
   181  LILSSRPKPS PPPPLILSPD LITTLADLFS PSPLRDPLPP QPVSPLDSKF PIDHSPPQQL
   241  PFPLLPPHHI ERVEPSLQPE ASLSLNTIFS FGSTLCQDIS QAVNRTDSCA RHHGPPTPSA
   301  LPPEDCTVTQ SKSNLTVLKT FPEMLSLGGS GGSSTSAPTT KGIDHSCPAS SEFSWWQPHA
   361  KDSFSSNFVP SDFMEELLTL HSSEASLGGH SVANIIQPVN ISFLSHDIPA LLERQVKRRG
   421  DFLMWKENGK KPGSFPTQLR PNYQLNSSRN MLTSTAVKHD LAESFPFWAS KGKLEWQHIH
   481  QQPPYSKCFE DHLEQKYVQL FWGLPSLHSE SLHPTVFVQH GRSSMFVFFN GITNTSMSHE
   541  SPVLPPPQPL FLPSTQPLPL PQTLPRGQSL HLTQVKSLAQ PQSPFPALPP SPLFLIRVCG
   601  VCFHRPQNEA RSLMPSEINH LEWNVLQKVQ ESVWGLPSVV QKSQEDFCPP APNPVLVRKS
   661  FKVHVPISII PGDFPLSSEV RKKLEQHIRK RLIQRRWGLP RRIHESLSLL RPQNKISELS
   721  VSESIHGPLN ISLVEGQRCN VLKKSASSFP RSFHERSSNM LSMENVGNYQ GCSQETAPKN
   781  HLLHDPETSS EEDLRSNSER DLGTHMMHLS GNDSGVRLGQ KQLENALTVH LSKKFEEINE
   841  GRMPGTVHSS WHSVKQTICL PEKSHSQIKH RNLAALVSED HRVDTSQEMS FLSSNKQKML
   901  EAHIKSFHMK PILNLSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

testis: 7.6 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 39 nCPM
late primary spermatocytes: 4.6 nCPM
late spermatids: 1.1 nCPM
mucous neck cells: 0.4 nCPM
peritubular myoid cells: 0.3 nCPM
t-cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31D3 as an antibody target. Whether an autoantibody or antibody against SPATA31D3 could matter depends on whether native SPATA31D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31D3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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