Seroatlas · Human Serome Atlas

SPATA31D1

Spermatogenesis-associated protein 31D1

Also known as: FAM75D1, FLJ46321, S31D1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZQQ2
Gene: SPATA31D1
Ensembl: ENSG00000214929
Chromosome: 9
Canonical length: 1576 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1576 residues, UniProt reviewed canonical sequence.

>Q6ZQQ2|SPATA31D1
     1  MENILCFLNS YTETGLSPDS HWLDIDPNFI CLSGLGLFIL YLFYVVLTLY SSPTEKNNDI
    61  QKHQGRAKRR RKGGTFKGFP DWKSFQREEE EERKLLSLLK SFGPPVSCSP RGQHHDTNHF
   121  RRLLCPDPVC RVCKRATADI QQLLSWESLK DAAPSVSPLA SSASATESSF TLASTPSATP
   181  PEDLILSPRP KASPPPPLIL SPDLITTLAD LFSPSPLRDP LPPQPVSPLD SKFPIDHSPP
   241  QQLPFPLLPP HHIERVESSL QPEASLSLNT IFSFGSTLCQ DISQAMNPID SCARHHGPPI
   301  PSALPPEDCT VTQSKSSLTI LKTFPEMLSL GGSGGSSTSA PTIKGIDHSH LASSEFTWWQ
   361  PHAKDSFSSN FVPSDFMEEL LTLHSSEAFL GGHSVANLIE PVNISFLSHD ILALLERQVK
   421  KRGDFLMWKE NGKKPGSFPK QLRPNYQLNS SRNMLTSIAV KHDLAESFPF WASKGKLEWQ
   481  HIHQQPPHSK CFEDHLEQKY VQLFWGLPSL HSESLHPTVL VQRGHSSMFV FFNGITNTSI
   541  SHESPVLPPP QPLSLPSTQP LPLPQTLPQG QSPHLTQVKS LAQPQSPFRA LLPSPLFLIR
   601  ICGVCFHRPQ NEARSLLPSE INHLEWNVLQ KVQESLWGLP SVVQKSQEDF CPPAPNPELV
   661  RKSFKVHVPI SIIPGDFPLS SEVRKKLEQH IRRRLIQRRW GLPRRIHESL SLLRPQSKIS
   721  ELSVSERIHG PLNISLVEGQ RCNVLKKSAS SFPRSFHERS SNMLSMENVG NYQGYSQETV
   781  PKDHLLHGPE TSSDKDLRSN SERDLETHMM HLSGNDSGVR LGQKQLENAL TVRLSKKFEE
   841  INEGRMPGTV HSSWHSVKQT MSLPEKSHSQ IKHRNLVTLV SEDHCVDTSQ EISFLSSNKQ
   901  KMLEAHIKTF RMRMLWGLPL KVLESIEIFK SKADLSTSFS HFDLPSSATF ISQGDSKDGV
   961  SKSRSRSTFQ GEKLGTTSSV PILDRPHPVS SPVVQEGQGT LRRQFSDTDH DLIETDSKDG
  1021  ASTSLRRGTT DFQSEKLDST SSFPILGHSY LVTSPVNQEK QGTLRREFSD TDNDLTESVR
  1081  TTEDGRQTFL PPPHSIVDEV SQKQTVLASR CSAELPIMQA GAGCESWDKR KSSFHNVDRL
  1141  QGSRKTFPVT NALQSQTRNN LTTSKSGSCS LTNVKASTSN ETEIFPPRIS VPQDPKSSYL
  1201  KNQMLSQLKL VQRKHSQPQS HFTDMSFALD NLSSKDLLTN SQGISSGDMG TSQVVHVHLE
  1261  DSGIRVAQKQ EPRVPTCVLQ KCQVTNFPPA VNRVSPVRPK GGELDGGDAG LGTSQRRRKS
  1321  LPVHNKTSGE VLGSKSSPTL KTQPPPENLF RKWMKTSLQW FNKPSISYEE QESSWEKGSS
  1381  LSSCVQNIGR VIRAAFTGTT EAQKIRKDTR EFLEEKLGHR HGIDITCPQE PLSFPVGLGK
  1441  AQHNPEVHVR AEPVQGCPCN YRAPSCKVTR TKSCSQQAIF VGQNYPTRIR QIIDKDRQPQ
  1501  KVEAFKGKIL CQSHPQSMPH RKPVPHPNPT CRRQVSLVCP AVPTSAKSPV FSDVPFLTGQ
  1561  KMLPKHLQGG KFPPTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 1 nCPM
late spermatids: 0.8 nCPM
early primary spermatocytes: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: -5.27
DepMap mean gene effect: 0.39
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31D1 as an antibody target. Whether an autoantibody or antibody against SPATA31D1 could matter depends on whether native SPATA31D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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