Seroatlas · Human Serome Atlas

SPATA31C1

Spermatogenesis-associated protein 31C1

Also known as: FAM75C1, FLJ36055, S31C1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DKV0
Gene: SPATA31C1
Ensembl: ENSG00000230246
Chromosome: 9
Canonical length: 1188 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1188 residues, UniProt reviewed canonical sequence.

>P0DKV0|SPATA31C1
     1  MENLPFPLKL LSASSLNTPS STPWVLDIFL TLVFALGLFF LLLPYFSYLR CDNPPSPSPR
    61  KRKRHLVSQR HLVSQCPTGR RGRPRGRMKN HSLRACRECP RGLEETWDLL SQLQSLLGPH
   121  LEKGDFGQLS GPDPPGEVGK RTPDGASRSS HEPMEDAAPI VSPLASPDPR TKHPQDLAST
   181  PPPGPMTTSV SSLSASQPPE PSLLLERPSP EPPALFPHPP HTPDPLACSP PPPKGFTPPP
   241  LRDSTLLTPS HCDSVALPLD TVPQSLSPRE DLAASVPAIS GLGGSNSQVS ALSWSQETTK
   301  TWCIFNSSVQ QDHLSRQRDT TMSPLLFQAQ PLSHLGPESQ PFISSTPQFR PTPMAQAEAQ
   361  AHLQSSFPVL SPAFLSPMKN TGVACPASQN KVQALSLPET QHPERPLLRK QLEGGLALPS
   421  RVQKSQDVFS VSTPNLPQER LTSILPENFP VSPELWRQLE QYMGQRGRIQ ESLDLMQLQD
   481  ELPGTSQAKG KPRPWQSSTS TGESSKEAQT VKFQLERDPC PHLGQILGET PQNLSRGMES
   541  FPGKVLGATS EESERNLRKP LRSDSGSDLL RRTERNHIEN ILKAHMGRKL GQTNEGLIPV
   601  SVRRSWLAVN QAFPVSNTHV KTSNLAAPKS RKACVNTAQV LSFLELCTQQ VLEAHIVRFW
   661  AKHRWGLPLR VLKPIQCFQL EKVSSLSLIQ LAGPSSDTCE SGAGSKVEVA TLLGEPPMAS
   721  LRKQVLTKPS VHMPERLQAS SPACKQFQRA PRGIPSSNDH GSLKAPTAGQ EGRWPSKPLT
   781  YSLKGSTQQS RSLGAQSSRA GETREAVPQP TVPLGTCMRA NLQATSEDVR GFKAPGASKS
   841  SLLPRMSVSQ DPRKLCLMEE AVSEFEPGMA TKSETQPQVS AAVVLLPDGQ ASVVPHASEN
   901  LASQVPQGHL QSTPTGNMQA SQELCDLMSA RRSNMGHKEP RNPNCQGSCK SQSPMFPPTH
   961  KRENSRKPNL EKHEEMFQGL RTPQLTPGRK TEDTRQNEGV QLLPSKKQPP SISHFGENIK
  1021  QFFETIFSKK ERKPAPVTAE SQKTVKNRSC VYGSSAEAER LMTAVGQIPE ENMSLCHARH
  1081  ASKVNQQRQQ FQAPVCGFPC NHRHPFYSDH SRMLSYAASS QQATLKNQSR PNRDRQIRDQ
  1141  QPLKSVRCNN EQWGLRHPQL LLPKKAVSPV SPPQHRPKTP SASSHHHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

testis: 6.9 nTPM
epididymis: 1.4 nTPM
bone marrow: 0.6 nTPM
cerebral cortex: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

early spermatids: 47 nCPM
late primary spermatocytes: 18 nCPM
late spermatids: 11 nCPM
megakaryocyte-erythroid progenitors: 0.7 nCPM
epididymal principal cells: 0.4 nCPM
erythrocyte progenitors: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 14 nTPM
cerebral cortex: 2 nTPM
midbrain: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
thalamus: 0.2 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31C1 as an antibody target. Whether an autoantibody or antibody against SPATA31C1 could matter depends on whether native SPATA31C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31C1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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