Seroatlas · Human Serome Atlas

SPATA31A3

Spermatogenesis-associated protein 31A3

Also known as: DKFZp434B204, FAM75A3, S31A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VYP0
Gene: SPATA31A3
Ensembl: ENSG00000275969
Chromosome: 9
Canonical length: 1347 aa
Protein class: Predicted membrane proteins
Subcellular location: Acrosome,Equatorial segment

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1347 residues, UniProt reviewed canonical sequence.

>Q5VYP0|SPATA31A3
     1  MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR CDDPPSPSPG
    61  KRKCPVGRRR RPRGRMKNHS LRAGRECRRG LEETSDLLSQ LQSLLGPHLD KGDFGQLSGP
   121  DPPGEVGERA PDGASQSSHE PMEDAAPILS LLASPDPQAK HPQDLASTPS PGPMTTSVSS
   181  LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSLPP PKGFTAPPLR DSTLITPSHC
   241  DSVALPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
   301  HLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF TNRMTPEKHL
   361  NSLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD PRLWQESFWK NYSQLFWGLP
   421  SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PLSHLGPECQ
   481  PFISSTPQFR PTPMAQAEAQ AHLQSSFPVL SPAFPSLIQN TGVACPASQN KVQALSLPET
   541  QHPEWPLLRR QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE
   601  QHIKKWIIQH WGNLGRIQES LDLMQLQDES PGTSQAKGKP SPWQSSMSTG ESSKEAQKVK
   661  FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE LERNLRKPLR SDSGSDLLRC
   721  TERTHIENIL KAHMGRNLGQ TNEGLIPVRV RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK
   781  ACVNTAQVLS FLEPCTQQGL GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA
   841  GPSSATCESG AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR
   901  GIPSWNDHEP LKPPPAGQEG RWPSKPLTYS LTGSTQQSRS LGAQSSKAGE TREAVPQCRV
   961  PLETCMLANL QATSEDVHGF EAPGTSKSSL HPRVSVSQDP RKLCLMEEVV SEFEPGMATK
  1021  SETQPQVCAA VVLLPDGQAS VVPHASENLV SQVPQGHLQS MPTGNMRASQ ELHDLMAARR
  1081  SKLVHEEPRK PNCQGSCKSQ RPMFPPIHKS EKFRKPNLEK HEERLEGLRT PQLTPVRKTE
  1141  DTHQDEGVQL LPSKKQPPSV SPFGENIKQI FQWIFSKKKS KPAPVTAESQ KTVKNRSCVY
  1201  SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH RHLFYSEHGR
  1261  ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ WGLRHPQILH PKKAVSPVSP
  1321  PQHWPKTSGA SSHHHHCPRH CLLWEGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

testis: 4.4 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 0.8 nCPM
early spermatids: 0.4 nCPM
late spermatids: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.3
gnomAD missense Z: -1.28
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31A3 as an antibody target. Whether an autoantibody or antibody against SPATA31A3 could matter depends on whether native SPATA31A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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