Seroatlas · Human Serome Atlas

SPATA31F2P

Putative protein SPATA31F2P

Also known as: S31F2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q63HN1
Gene: SPATA31F2P
Canonical length: 556 aa

OverviewNCBI Gene

No narrative summary is available for SPATA31F2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>Q63HN1|SPATA31F2P
     1  MHPMALHMVL PAHLPFLSPE VLRLLEVHVK KWMHFQRWGL PRRVEESLRQ LMPNPPLYYQ
    61  PGNDQPVSFN LNNTSQVSLH RSETISLQTW CSCVAGQPIQ TFWVSEWSTM NPEQRHHCQQ
   121  TPNPMALALP SPALKALSGP HPQSGGQDND SGSDLQQKYS QLFCGLPSLH SESLVATFMG
   181  SQGLPKIENV PKPPLKDPFL FNDLSFPQLL PKTSPQSAPP SSPLSPNWVS PSDHQRAQIN
   241  VPFLTLAEYE ALEWHLLQRQ LQLQWGWPAA LQRSQHTQCL MQHEPCGKAQ SPETTTASQT
   301  GKSISVLTRE LLFFPEHARK LLEFHIQKQS IRHRWGLPQK IQQSIQLLLT STDQQTVSSS
   361  STALANVSIP QPVALEANGA CDVLSPIAAP VSIPRPHLLT QVKAILQSHI DSKCGQIHQG
   421  KIPACVHRSW DCRISGVLAV APFPCIPESQ FLVLQTASDP DLHHKVMPWM PTALDQQQQA
   481  LPGTVTEHPK LLRVLSVEAI EKLETTLRHK HLAFLSGLPA LYYVALPRAL APAVTSQSVI
   541  TEMEPSPVEI PAEPLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31F2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31F2P as an antibody target. Whether an autoantibody or antibody against SPATA31F2P could matter depends on whether native SPATA31F2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31F2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31F2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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