Seroatlas · Human Serome Atlas

SPATA31E1

Spermatogenesis-associated protein 31E1

Also known as: C9orf79, FAM75E1, FLJ35866, S31E1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUB1
Gene: SPATA31E1
Ensembl: ENSG00000177992
Chromosome: 9
Canonical length: 1445 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1445 residues, UniProt reviewed canonical sequence.

>Q6ZUB1|SPATA31E1
     1  MGNLVIPLGK GRAGRVESGQ RIPPPAPRPS VECTGDDIAL QMEKMLFPLK SPSATWLSPS
    61  STPWMMDFIL TSVCGLVLLF LLLLYVHSDP PSPPPGRKRS SREPQRERSG RSRSRKISAL
   121  KACRILLREL EETRDLNYLL ESHLRKLAGE GSSHLPLGGD PLGDVCKPVP AKAHQPHGKC
   181  MQDPSPASLS PPAPPAPLAS TLSPGPMTFS EPFGPHSTLS ASGPPEPLLP LKCPATQPHV
   241  VFPPSPQPHG PLASSPPPPD SSLAGLQCGS TTCPVPQSSP LHNQVLPPPT RVISGLGCSS
   301  DPIWDLYCWR EAATTWGLST YSHGKSQPRH LPDHTSEASF WGDPTPKHME VGGCTFIHPD
   361  VQKLLETLIA KRALMKMWQE KERKRADHPH MTSLGKEWDI TTLNPFWNVS TQPQQLPRPQ
   421  QVSDATTVGN HLQQKRSQLF WDLPSLNSES LATTVWVSRN PSSQNAHSVP LDKASTSLPG
   481  EPEVEASSQL SQAPPQPHHM AQPQHFTPAW PQSQPPPLAE IQTQAHLSPP VPSLGCSSPP
   541  QIRGCGASYP TSQERTQSVI PTGKEYLEWP LKKRPKWKRV LPSLLKKSQA VLSQPTAHLP
   601  QERPASWSPK SAPILPGVVT SPELPEHWWQ GRNAIHQEQS CGPPSRLQAS GDLLQPDGEF
   661  PGRPQSQAED TQQALLPSQP SDFAGKGRKD VQKTGFRSSG RFSDKGCLGS KLGPDPSRDQ
   721  GSGRTSVKAL DEDKEAEGDL RRSWKYQSVS STPRDPDKEH LENKLQIHLA RKVGEIKEGW
   781  IPMPVRRSWL MAKCAVPKSD THRKPGKLAS WRGGKAHVNT SQELSFLHPC TQQILEVHLV
   841  RFCVRHSWGT DLQSLEPINV WSGEAQAPPF PQSTFTPWAS WVSRVESVPK VPIFLGKRPQ
   901  NGPGDNRTTS KSVPTVSGPL AAPPPEQEGV QRPPRGSQSA DTHGRSEAFP TGHKGRGCSQ
   961  PPTCSLVGRT WQSRTVLESG KPKPRLEGSM GSEMAGNEAW LESESMSPGD PCSSRALQVL
  1021  SIGSQWARAE DALQALKVGE KPPTWEVTLG ASVRASSGSV QEDLRSTGAL GTTGNPSASS
  1081  VCVAQDPEQL HLKAQVVSEI ALIVQVDSEE QLPGRAPGIL LQDGATGLCL PGRHMDMLTA
  1141  ADRLPTQAPL STSQSVSGKN MTASQGPCAL LWKGGDSPGQ QEPGSPKAKA PQKSQKTLGC
  1201  ADKGEAHRRP RTGEQGHRSK GPRTSEASGR SHPAQAREIG DKQERKYNQL QLEKGQTPPE
  1261  SHFQRKISHH PQGLHPRKGG TRWEDVLQKG KPGADAFQSW GSGPPRQFMD CMADKAWTIS
  1321  RVVGQILVDK LGLQWGRGPS EVNRHKGDFR AQENVPSCCH RGHCHQERSR EMRALACSPK
  1381  ATPKGHHCPV KNRGIRDRDS SWAPPPREPV SPAGPHHHRP RMASTSGGPH PQLQELMSAQ
  1441  RCLAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 7.1 nTPM

Expression across tissuesHPA

Tissue

testis: 7.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 67 nCPM
late spermatids: 21 nCPM
late primary spermatocytes: 2.6 nCPM
foveolar cells: 0.6 nCPM
leydig cells: 0.4 nCPM
mesothelial cells: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 15 nTPM
cerebral cortex: 1.2 nTPM
amygdala: 0.1 nTPM
midbrain: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0.03
gnomAD missense Z: -2.13
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31E1 as an antibody target. Whether an autoantibody or antibody against SPATA31E1 could matter depends on whether native SPATA31E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31E1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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