Seroatlas · Human Serome Atlas

SPATA31A1

Spermatogenesis-associated protein 31A1

Also known as: C9orf36, C9orf36A, DKFZP434B204, FAM75A1, FAM75A2, S31A1_HUMAN, SPATA31A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TZJ5
Gene: SPATA31A1
Ensembl: ENSG00000204849
Chromosome: 9
Canonical length: 1347 aa
Protein class: Predicted membrane proteins
Subcellular location: Acrosome,Equatorial segment

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1347 residues, UniProt reviewed canonical sequence.

>Q5TZJ5|SPATA31A1
     1  MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR CDDPPSPSPG
    61  KRKCPVGRRR RPRGRMKNHS LRAGRECPRG LQETSDLLSQ LQSLLGPHLD KGDFGQLSGP
   121  DPPGEVGERA PDGASQSSHE PMEDAAPILS PLASPDPQAK HPQDLASTPS PGPMTTSVSS
   181  LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSPPP PKGFTAPPLR DSTLITPSHC
   241  DSVALPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
   301  HLSRHPPETY QMEAGSLFLL SSDGQNAVGI QVTETAKVNI WEEKENVGSF TDRMTPEKHL
   361  NSLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD PRLWQESFWK NYSQLFWGLP
   421  SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PPSHLGPECQ
   481  PFISSTPQFR PTPMAQAEAQ AHLQSSFPVL SPAFPSLIKN TGVACPASQN KVQALSLPET
   541  QHPEWPLLRR QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE
   601  QHIKKWIIQH WGNLGRIQES LDLMQLRDES PGTSQAKGKP SPWQSSMSTG ESSKEAQKVK
   661  FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE SERNLRKPLR SDSGSDLLRC
   721  TERTHIENIL KAHMGRNLGQ TNEGLIPVRV RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK
   781  ACVNTAQVLS FLEPCTQQGL GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA
   841  GPSSATCESG AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR
   901  GIPSWNDHGP LKPPPAGQEG RWPSKPLTYS LTGSTQQSRS LGAQSSKAGE TREAVPQCRV
   961  PLETCMLANL QATSEDMHGF EAPGTSKSSL HPRVSVSQDP RKLCLMEEVV NEFEPGMATK
  1021  SETQPQVCAA VVLLPDGQAS VVPHASENLV SQVPQGHLQS MPAGNMRASQ ELHDLMAARR
  1081  SKLVHEEPRN PNCQGSCKNQ RPMFPPIHKS EKSRKPNLEK HEERLEGLRT PQLTPVRKTE
  1141  DTHQDEGVQL LPSKKQPPSV SHFGGNIKQF FQWIFSKKKS KPAPVTAESQ KTVKNRSCVY
  1201  SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH RHLFYSEHGR
  1261  ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ WGLRHPQILH PKKAVSPVSP
  1321  LQHWPKTSGA SSHHHHCPRH CLLWEGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

testis: 8.4 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 16 nCPM
late primary spermatocytes: 10 nCPM
late spermatids: 1.7 nCPM
schwann cells: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.38
gnomAD missense Z: -0.66
DepMap mean gene effect: 0
DepMap dependency class: none

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31A1 as an antibody target. Whether an autoantibody or antibody against SPATA31A1 could matter depends on whether native SPATA31A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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