Seroatlas · Human Serome Atlas

SPATA31A6

Spermatogenesis-associated protein 31A6

Also known as: FAM75A6, S31A6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VVP1
Gene: SPATA31A6
Ensembl: ENSG00000185775
Chromosome: 9
Canonical length: 1343 aa
Protein class: Predicted membrane proteins
Subcellular location: Acrosome,Equatorial segment

OverviewNCBI Gene

Predicted to enable actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1343 residues, UniProt reviewed canonical sequence.

>Q5VVP1|SPATA31A6
     1  MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFH CDDPPSPSPG
    61  KRKCPVGRRR RPRGRMKNHS LRAGRECPRG LEETSDLLSQ LQSLLGPHLD KGDFGQLSGP
   121  DPPGEVGERA PDGASQSSHE PMEDAAPILS PLASPDPQAK HPQDLASTPS PGPMTTSVSS
   181  LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSPPP PKGFTAPPLR DSTLITPSHC
   241  DSVALPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
   301  PLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF TNQMTPEKHL
   361  NSLGNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKCSD PRLLQESFWK NYSQLFWGLP
   421  SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PLSHRQPFIS
   481  STPQFLPTPM AQAEAQAHLQ SSFPVLSPAF PSLIKNTGVA CPASQNKVQA LSLPETQHPE
   541  WPLLRKQLEG RLALPSRVQK SQDVFSVSTP NLPQESLTSI LPENFPVSPE LRRQLEQHIK
   601  KWIIQHWGNL GRIQESLDLM QLRDESPGTS QAKGKPSPWQ SSTSTGESSK EAQKVKFQLE
   661  RDLCPHLGQI LGETPQNLSR DMKSFPRKVL GVTSEESERN LRKPLRSDSG SDLLRCTERT
   721  HIENILKAHM GRNLGQTNEG LIPVRVRRSW LAVNQALPVS NTHVKTSNLA APKSGKACVN
   781  TAQVLSFLEP CTQQGLGAHI VRFWAKHRWG LPLRVLKPIQ CFKLEKVSSL SLTQLAGPSS
   841  ATCESGAGSE VEVDMFLRKP PMASLRKQVL TKASDHMPES LLASSPAWKQ FQRAPRGIPS
   901  WNDHGPLKPP PAGQEGRWPS KPLTYSLTGS TQQSRSLGAQ SSKAGETREA VPQCRVPLET
   961  CMLANLQATS EDVHGFEAPG TSKSSLHPRV SVSQDPRKLC LMEEVVSEFE PGMATKSETQ
  1021  PQVCAAVVLL PDGQASVVPH ASENLVSQVP QGHLQSMPTG NMRASQELHD LMAARRSKLV
  1081  QEEPRNPNCQ GSCKSQRPMF PPIHKSEKSR KPNLEKHEER LEGLRTPQLT PVRKTEDTHQ
  1141  DEGVQLLPSK KQPPSVSHFG ENIKQFFQWI FSKKKSKPAP VTAESQKTVK NRSCVYSSSA
  1201  EAQGLMTAVG QMLDKKMSLC HAHHASKVNQ HKQKFQAPVC GFPCNHRHLF YSEHGRILSY
  1261  AASSQQATLK SQGCPNRDRQ IRNQQPLKSV RCNNEQWGLR HPQILHPKKA VSPVSPPQHW
  1321  PKTSGASSHH HHCPRHCLLW EGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA31A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

testis: 1.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 0.4 nCPM
early spermatids: 0.3 nCPM
late primary spermatocytes: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.3 nTPM
hippocampal formation: 0.3 nTPM
midbrain: 0.2 nTPM
cerebral cortex: 0.1 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -4.59
DepMap mean gene effect: -0.6
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA31A6 as an antibody target. Whether an autoantibody or antibody against SPATA31A6 could matter depends on whether native SPATA31A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA31A6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA31A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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