Keratin type II head
IPR032444
Definition
All intermediate filament proteins feature a central α-helical rod domain and variable nonhelical domains located at the N-terminal (head) and C-terminal (tail). The central rod domain is the main driver of self-assembly into filaments, whereas the N- and C-terminal domains are involved in post-translational modifications and interactions with other proteins PMID:16710422. Type I and type II keratin form heteropolymeric intermediate filaments providing vital mechanical support in epithelia PMID:22705788. This entry represents the N-terminal domain (head) of type II keratins.
25 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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