Shisa

Definition

Shisa is a transmembrane, transcription factor-type protein that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface [[cite:PMID:15680320], [cite:PMID:18033675]]. The Shisa family founding member, Xenopus Shisa, promotes head development by antagonising Wnt and FGF signaling PMID:15680328. Several vertebrate homologues have been identified with implicated roles in development, cancer and apoptosis [[cite:PMID:16773659], [cite:PMID:18954025], [cite:PMID:12135983]]. Distantly related Shisa homologues have also been detected that possess an N-terminal domain with six conserved cysteines. These Shisa-like proteins include SHISAL1 (shisa-like-1, also known as KIAA1644), SHISAL2A (FAM159A) and SHISAL2B (FAM159B) from vertebrates PMID:22120523.

11 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (11 proteins: gene, accession, name)

• SHISA2
• SHISA3
• SHISA4
• SHISA5
• SHISA6
• SHISA7
• SHISA8
• SHISA9
• SHISAL1
• SHISAL2A
• SHISAL2B