Gamma-carboxyglutamic acid-rich (GLA) domain

Definition

The GLA (gamma-carboxyglutamic acid-rich) domain contains glutamate residues that have been post-translationally modified by vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla) [[cite:PMID:18374189], [cite:PMID:11818531], [cite:PMID:18374194]]. All glutamic acid (Glu) residues present in the GLA domain are potential carboxylation sites; in coagulation proteins, all Gu residues are modified to Gla, while in osteocalcin and matrix Gla proteins only some Glu residues are modified to Gla.

14 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (14 proteins: gene, accession, name)

• BGLAP
• F10
• F2
• F7
• F9
• GAS6
• MGP
• PROC
• PROS1
• PROZ
• PRRG1
• PRRG2
• PRRG3
• PRRG4