PRRG4
Transmembrane gamma-carboxyglutamic acid protein 4
Also known as: TMG4, TMG4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BZD6
- Gene
- PRRG4
- Ensembl
- ENSG00000135378
- Chromosome
- 11
- Canonical length
- 226 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
Enables WW domain binding activity. Predicted to be involved in blood coagulation. Located in plasma membrane. Biomarker of cholangiocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
226 residues, UniProt reviewed canonical sequence.
>Q9BZD6|PRRG4
1 MFTLLVLLSQ LPTVTLGFPH CARGPKASKH AGEEVFTSKE EANFFIHRRL LYNRFDLELF
61 TPGNLERECN EELCNYEEAR EIFVDEDKTI AFWQEYSAKG PTTKSDGNRE KIDVMGLLTG
121 LIAAGVFLVI FGLLGYYLCI TKCNRLQHPC SSAVYERGRH TPSIIFRRPE EAALSPLPPS
181 VEDAGLPSYE QAVALTRKHS VSPPPPYPGH TKGFRVFKKS MSLPSHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRRG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 22 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 22 nTPM
- liver: 21 nTPM
- skin: 20 nTPM
- vagina: 13 nTPM
- kidney: 12 nTPM
- salivary gland: 9.2 nTPM
Single-cell type
- esophageal apical cells: 424 nCPM
- ocular epithelial cells: 379 nCPM
- esophageal suprabasal cells: 335 nCPM
- urothelial cells: 245 nCPM
- suprabasal keratinocytes: 214 nCPM
- esophageal basal cells: 196 nCPM
Immune cell
- neutrophil: 12 nTPM
- classical monocyte: 2.3 nTPM
- intermediate monocyte: 0.8 nTPM
- non-classical monocyte: 0.8 nTPM
- basophil: 0.7 nTPM
- myeloid DC: 0.5 nTPM
Brain region
- choroid plexus: 6 nTPM
- hypothalamus: 4.7 nTPM
- medulla oblongata: 4.1 nTPM
- pons: 3.8 nTPM
- white matter: 3.7 nTPM
- thalamus: 3.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.83
- gnomAD pLI
- 0.11
- gnomAD missense Z
- 1.31
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PRRG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRRG4 as an antibody target. Whether an autoantibody or antibody against PRRG4 could matter depends on whether native PRRG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRRG4 is annotated at the cell surface, where native PRRG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PRRG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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