Seroatlas · Human Serome Atlas

PRRG1

Transmembrane gamma-carboxyglutamic acid protein 1

Also known as: PRGP1, TMG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14668
Gene: PRRG1
Ensembl: ENSG00000130962
Chromosome: X
Canonical length: 218 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>O14668|PRRG1
     1  MGRVFLTGEK ANSILKRYPR ANGFFEEIRQ GNIERECKEE FCTFEEAREA FENNEKTKEF
    61  WSTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL IWRCFLRNKT RRQTVTEGHI
   121  PFPQHLNIIT PPPPPDEVFD SSGLSPGFLG YVVGRSDSVS TRLSNCDPPP TYEEATGQVN
   181  LQRSETEPHL DPPPEYEDIV NSNSASAIPM VPVVTTIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 40 nTPM
midbrain: 20 nTPM
skeletal muscle: 15 nTPM
hippocampal formation: 15 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 10 nTPM

Single-cell type

oligodendrocytes: 235 nCPM
bergmann glia: 40 nCPM
myonuclei: 37 nCPM
vascular endothelial cells: 33 nCPM
lymphatic endothelial cells: 27 nCPM
astrocytes: 26 nCPM

Immune cell

basophil: 0.7 nTPM
classical monocyte: 0.3 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 79 nTPM
medulla oblongata: 56 nTPM
basal ganglia: 51 nTPM
cerebellum: 45 nTPM
pons: 44 nTPM
midbrain: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0.13
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRG1 as an antibody target. Whether an autoantibody or antibody against PRRG1 could matter depends on whether native PRRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRG1 is annotated at the cell surface, where native PRRG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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