Seroatlas · Human Serome Atlas

PRRG2

Transmembrane gamma-carboxyglutamic acid protein 2

Also known as: PRGP2, TMG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14669
Gene
PRRG2
Ensembl
ENSG00000126460
Chromosome
19
Canonical length
202 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>O14669|PRRG2
     1  MRGHPSLLLL YMALTTCLDT SPSEETDQEV FLGPPEAQSF LSSHTRIPRA NHWDLELLTP
    61  GNLERECLEE RCSWEEAREY FEDNTLTERF WESYIYNGKG GRGRVDVASL AVGLTGGILL
   121  IVLAGLGAFW YLRWRQHRGQ QPCPQEAGLI SPLSPLNPLG PPTPLPPPPP PPPGLPTYEQ
   181  ALAASGVHDA PPPPYTSLRR PH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 27 nTPM
  • pituitary gland: 15 nTPM
  • esophagus: 13 nTPM
  • thyroid gland: 13 nTPM
  • pancreas: 12 nTPM
  • epididymis: 12 nTPM

Single-cell type

  • esophageal apical cells: 85 nCPM
  • enterocytes: 46 nCPM
  • colonocytes: 42 nCPM
  • esophageal suprabasal cells: 40 nCPM
  • epididymal principal cells: 38 nCPM
  • breast lactating cells: 33 nCPM

Immune cell

  • plasmacytoid DC: 1.2 nTPM
  • neutrophil: 0.5 nTPM
  • gdT-cell: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • cerebellum: 1.7 nTPM
  • cerebral cortex: 1.4 nTPM
  • thalamus: 1.4 nTPM
  • medulla oblongata: 1.3 nTPM
  • pons: 1.3 nTPM
  • hypothalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
-0.09
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRRG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRG2 as an antibody target. Whether an autoantibody or antibody against PRRG2 could matter depends on whether native PRRG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRG2 is annotated at the cell surface, where native PRRG2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRRG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRRG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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