Seroatlas · Human Serome Atlas

BGLAP

Osteocalcin

Also known as: OCN, OSTCN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P02818
Gene: BGLAP
Ensembl: ENSG00000242252
Chromosome: 1
Canonical length: 100 aa
Protein class: FDA approved drug targets, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>P02818|BGLAP
     1  MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR RYLYQWLGAP
    61  VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BGLAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

colon: 18 nTPM
spinal cord: 13 nTPM
basal ganglia: 12 nTPM
midbrain: 12 nTPM
amygdala: 11 nTPM
cerebral cortex: 8.5 nTPM

Single-cell type

plasma cells: 4.8 nCPM
oligodendrocytes: 2.9 nCPM
oligodendrocyte progenitor cells: 2.7 nCPM
astrocytes: 2.6 nCPM
choroid plexus epithelial cells: 2.2 nCPM
brain excitatory neurons: 2.1 nCPM

Immune cell

NK-cell: 1.8 nTPM
plasmacytoid DC: 1.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 10 nTPM
white matter: 9.9 nTPM
spinal cord: 9 nTPM
basal ganglia: 8.5 nTPM
midbrain: 7.9 nTPM
thalamus: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BGLAP as an antibody target. Whether an autoantibody or antibody against BGLAP could matter depends on whether native BGLAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BGLAP is annotated as secreted, so native BGLAP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BGLAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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