Seroatlas · Human Serome Atlas

PRRG3

Transmembrane gamma-carboxyglutamic acid protein 3

Also known as: TMG3, TMG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZD7
Gene: PRRG3
Ensembl: ENSG00000130032
Chromosome: X
Canonical length: 231 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>Q9BZD7|PRRG3
     1  MAVFLEAKDA HSVLKRFPRA NEFLEELRQG TIERECMEEI CSYEEVKEVF ENKEKTMEFW
    61  KGYPNAVYSV RDPSQSSDAM YVVVPLLGVA LLIVIALFII WRCQLQKATR HHPSYAQNRY
   121  LASRAGHTLP RVMVYRGTVH SQGEPSGHRE AANSPQVVLG PSRGGRTTVR LESTLYLPEL
   181  SLSRLSSTTP PPSYEEVTAP QESSSEEASV SYSDPPPKYE EIVAANPGAD K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 11 nTPM
basal ganglia: 9.7 nTPM
cerebral cortex: 9.7 nTPM
epididymis: 7 nTPM
hippocampal formation: 5.2 nTPM
amygdala: 5.1 nTPM

Single-cell type

other brain neurons: 18 nCPM
brain inhibitory neurons: 14 nCPM
brain excitatory neurons: 13 nCPM
medullary thymic epithelial cells: 12 nCPM
fibro-adipogenic progenitors: 8.7 nCPM
fibroblasts: 8.5 nCPM

Immune cell

basophil: 1.2 nTPM
neutrophil: 0.7 nTPM
NK-cell: 0.5 nTPM
non-classical monocyte: 0.4 nTPM
eosinophil: 0.3 nTPM
MAIT T-cell: 0.3 nTPM

Brain region

cerebral cortex: 34 nTPM
basal ganglia: 34 nTPM
hypothalamus: 31 nTPM
white matter: 29 nTPM
pons: 23 nTPM
hippocampal formation: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -0.76
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRG3 as an antibody target. Whether an autoantibody or antibody against PRRG3 could matter depends on whether native PRRG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRG3 is annotated as secreted, so native PRRG3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRRG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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