Seroatlas · Human Serome Atlas

MGP

Matrix Gla protein

Also known as: MGP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08493
Gene
MGP
Ensembl
ENSG00000111341
Chromosome
12
Canonical length
103 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>P08493|MGP
     1  MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW RAKVQERIRE
    61  RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR GTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
15,728 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 15,728 nTPM
  • breast: 3,496 nTPM
  • heart muscle: 2,767 nTPM
  • fallopian tube: 2,403 nTPM
  • salivary gland: 1,985 nTPM
  • endometrium: 1,853 nTPM

Single-cell type

  • breast secretory cells: 17,168 nCPM
  • breast hormone-responsive cells: 10,283 nCPM
  • fibroblasts: 4,591 nCPM
  • salivary acinar cells: 4,296 nCPM
  • breast myoepithelial cells: 2,793 nCPM
  • vascular smooth muscle cells: 2,108 nCPM

Immune cell

  • plasmacytoid DC: 1.6 nTPM
  • gdT-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 330 nTPM
  • cerebral cortex: 56 nTPM
  • basal ganglia: 48 nTPM
  • thalamus: 39 nTPM
  • medulla oblongata: 33 nTPM
  • spinal cord: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MGP.

Disease | AllUniProt

Conditions MGP is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 134 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Keutel syndrome

Disease | ImmuneIEDB

Conditions an epitope on MGP was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.66
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGP as an antibody target. Whether an autoantibody or antibody against MGP could matter depends on whether native MGP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGP is annotated as secreted, so native MGP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MGP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MGP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...