Seroatlas · Human Serome Atlas

SURF4

Surfeit locus protein 4

Also known as: ERV29, FLJ22993, MGC102753, SURF4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15260
Gene
SURF4
Ensembl
ENSG00000148248
Chromosome
9
Canonical length
269 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nuclear membrane,Endoplasmic reticulum,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>O15260|SURF4
     1  MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE QRDYIDTTWN
    61  CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI IALQTIAYSI LWDLKFLMRN
   121  LALGGGLLLL LAESRSEGKS MFAGVPTMRE SSPKQYMQLG GRVLLVLMFM TLLHFDASFF
   181  SIVQNIVGTA LMILVAIGFK TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF
   241  QTMSVIGGLL LVVALGPGGV SMDEKKKEW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SURF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
216 nTPM

Expression across tissuesHPA

Tissue

  • liver: 216 nTPM
  • pancreas: 147 nTPM
  • adrenal gland: 104 nTPM
  • adipose tissue: 94 nTPM
  • pituitary gland: 86 nTPM
  • stomach: 86 nTPM

Single-cell type

  • oligodendrocytes: 41 nCPM
  • oligodendrocyte progenitor cells: 35 nCPM
  • papillary tip epithelial cells: 30 nCPM
  • microglia: 30 nCPM
  • bergmann glia: 29 nCPM
  • other brain neurons: 29 nCPM

Immune cell

  • total PBMC: 69 nTPM
  • MAIT T-cell: 57 nTPM
  • gdT-cell: 52 nTPM
  • memory CD8 T-cell: 48 nTPM
  • T-reg: 47 nTPM
  • basophil: 44 nTPM

Brain region

  • choroid plexus: 43 nTPM
  • thalamus: 40 nTPM
  • white matter: 38 nTPM
  • medulla oblongata: 34 nTPM
  • spinal cord: 32 nTPM
  • hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.61
gnomAD missense Z
2.11
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SURF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SURF4 as an antibody target. Whether an autoantibody or antibody against SURF4 could matter depends on whether native SURF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SURF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SURF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SURF4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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