WASH1

Definition

This entry represents members of the WASH1 family, which are components of the WASH complex that is present at the surface of endosomes and activates the Arp2/3-mediated F-actin polymerisation PMID:19922875. WASH1 contains N-terminal WASH homology regions (also known as the WAHD domain, which covers the WHD1/EVH1 and WHD2 domains), a proline-rich region and a C-terminal WH2 domain PMID:19922874. WASH1 localises to early endosomal subdomains through an essential interaction with FAM21 via its WHD1 domain and directly binds tubulin through its WHD2 domain, while linking to Arp2/3-mediated F-actin polymerisation via its C-terminal WH2 domain PMID:19922874.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• WASH2P
• WASH3P
• WASH4P
• WASH6P
• WASHC1
• WIPF3