MZT2A
Mitotic-spindle organizing protein 2A
Also known as: FAM128A, MOZART2A, MZT2A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P582
- Gene
- MZT2A
- Ensembl
- ENSG00000173272
- Chromosome
- 2
- Canonical length
- 158 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Centrosome,Cytosol
OverviewNCBI Gene
Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>Q6P582|MZT2A
1 MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGG IDPDVFKILV
61 DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS SVPETRGRDK GSAALGGVLA
121 LAERSNHEGS SQRMPRQPSA TRLPKGGGPG KSPTQGSTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MZT2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 244 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 244 nTPM
- amygdala: 186 nTPM
- cerebral cortex: 159 nTPM
- hippocampal formation: 149 nTPM
- basal ganglia: 121 nTPM
- hypothalamus: 108 nTPM
Single-cell type
- epididymal efferent duct absorptive cells: 597 nCPM
- esophageal apical cells: 549 nCPM
- epididymal principal cells: 507 nCPM
- esophageal suprabasal cells: 461 nCPM
- esophageal basal cells: 422 nCPM
- enteric transient amplifying cells: 316 nCPM
Immune cell
- eosinophil: 80 nTPM
- memory B-cell: 33 nTPM
- basophil: 22 nTPM
- T-reg: 22 nTPM
- naive CD4 T-cell: 21 nTPM
- memory CD4 T-cell: 19 nTPM
Brain region
- hippocampal formation: 85 nTPM
- amygdala: 83 nTPM
- cerebral cortex: 83 nTPM
- thalamus: 77 nTPM
- basal ganglia: 76 nTPM
- pons: 70 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.96
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.3
- DepMap mean gene effect
- -0.43
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MZT2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MZT2A as an antibody target. Whether an autoantibody or antibody against MZT2A could matter depends on whether native MZT2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MZT2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MZT2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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