Seroatlas · Human Serome Atlas

KIZ

Centrosomal protein kizuna

Also known as: C20orf19, HT013, KIZ_HUMAN, NCRNA00153, PLK1S1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M2Z5
Gene: KIZ
Ensembl: ENSG00000088970
Chromosome: 20
Canonical length: 673 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>Q2M2Z5|KIZ
     1  MSRTLASAVP LSSPDYYERL GQLQHGLRDS EKKRLDLEKK LYEYNQSDTC RVKLKYVKLK
    61  NYLKEICESE KKAHTRNQEY LKRFERVQAH VVHFTTNTEK LQKLKLEYET QIKKMLCSKD
   121  SLGLKEELTD EDREKVAVHE GINSGTAMSR GLYQPATIFM GRQMSAILSM RDFSTEHKSP
   181  QPTKNFSIPD PHSHRQTAQS SNVTDSCVVQ TSNDTQCLNK SDNIDGKASL QIGEKMPVTA
   241  SVLSEEEQTH CLEIGSNTRH GKSNLSEGKK SAELNSPLRE RLSPENRTTD LKCDSSSGSE
   301  GEILTREHIE VEEKRASPPV SPIPVSEYCE SENKWSQEKH SPWEGVSDHL AHREPKSQKP
   361  FRKMQEEEEE SWSTSSDLTI SISEDDLILE SPEPQPNPGG KMEGEDGIEA LKLIHAEQER
   421  VALSTEKNCI LQTLSSPDSE KESSTNAPTR EPGQTPDSDV PRAQVGQHVA TLKEHDNSVK
   481  EEATALLRKA LTEECGRRSA IHSSESSCSL PSILNDNSGI KEAKPAVWLN SVPTREQEVS
   541  SGCGDKSKKE NVAADIPITE TEAYQLLKKA TLQDNTNQTE NRFQKTDASV SHLSGLNIGS
   601  GAFETKTANK IASEASFSSS EGSPLSRHEN KKKPVINLKS NALWDESDDS NSEIEAALRP
   661  RNHNTDDSDD FYD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

colon: 69 nTPM
testis: 42 nTPM
urinary bladder: 39 nTPM
ovary: 34 nTPM
spinal cord: 31 nTPM
cervix: 29 nTPM

Single-cell type

oligodendrocyte progenitor cells: 299 nCPM
early spermatids: 290 nCPM
renal collecting duct principal cells: 253 nCPM
lactotrophs: 211 nCPM
oligodendrocytes: 211 nCPM
thyrotrophs: 205 nCPM

Immune cell

neutrophil: 17 nTPM
T-reg: 14 nTPM
naive CD8 T-cell: 13 nTPM
eosinophil: 13 nTPM
MAIT T-cell: 12 nTPM
memory B-cell: 12 nTPM

Brain region

white matter: 57 nTPM
pons: 48 nTPM
basal ganglia: 44 nTPM
medulla oblongata: 44 nTPM
thalamus: 40 nTPM
midbrain: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIZ.

Disease | AllUniProt

Conditions KIZ is implicated in, by any mechanism.

Retinitis pigmentosa 69 (RP69) MIM:615780

Disease | GeneticClinVar

53 pathogenic / likely-pathogenic of 507 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Retinitis pigmentosa 69
Retinal dystrophy
Retinitis pigmentosa
KIZ-related retinopathy
KIZ-related disorder

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spindle organization

Molecular functions

protein kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centrosomal protein kizuna

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIZ as an antibody target. Whether an autoantibody or antibody against KIZ could matter depends on whether native KIZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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